ReviewChildren (Basel, Switzerland)2021
Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review.
Review in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Neuroimaging and machine learning in eating disorders: a systematic review.Eating and weight disorders : EWD · 2025Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Dysregulation of Hippocampal Autophagic Machinery in the Activity-Based Anorexia Rat Model.Journal of neurochemistry · 2026Article
- Glucocorticoid signalling dysregulation and immune cell adaptation in Anorexia Nervosa.Molecular psychiatry · 2026Article
- Eating and Mental Health Disorders.Nutrients · 2026Article
- Shared and disorder-specific resting-state neural activity characteristics in patients with anorexia nervosa and bulimia nervosa.Journal of eating disorders · 2026Article
- Central autonomic network-heart interplay in anorexia nervosa. A cross-spectral dynamic causal modeling study.NeuroImage. Clinical · 2026Article
- Dysregulation of neurodevelopmental regulatory networks in Anorexia Nervosa: an integrated multi-layered omics analysis.Frontiers in cell and developmental biology · 2026Article
- Towards molecular diagnostics of parental alienation.Cellular and molecular life sciences : CMLS · 2025Review
- Brain morphology in adolescent girls with first-onset anorexia nervosa.European child & adolescent psychiatry · 2025Article
- Restrained Eating Features and Brain Morphology: A Pediatric Population-Based Study.The International journal of eating disorders · 2025Article
- Mapping the Mind: Gray Matter Signatures of Personality Pathology in Female Adolescent Anorexia Nervosa Persist Through Treatment.Journal of clinical medicine · 2025Article
- The Impact of Age on Gray Matter Volume Reduction in Anorexia Nervosa: A Systematic Review.medRxiv : the preprint server for health sciences · 2025Article
- Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa.NeuroImage. Clinical · 2025Article
- Mapping gray matter changes in anorexia nervosa: a functional connectivity network approach.Frontiers in nutrition · 2025Article
- Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design.Journal of eating disorders · 2024Review
- Anorexia nervosa in children and adolescents: an early detection of risk factors.Italian journal of pediatrics · 2024Article
- Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.BMC medical imaging · 2024Review
- Associations between parental rearing style and amygdala and hippocampal subfield abnormalities in drug-naive females with anorexia nervosa.BMC psychiatry · 2024Article
- Anorexia Nervosa Across the Lifespan: A Review of Recent Literature.Focus (American Psychiatric Publishing) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnorexia nervosa (AN) is a serious, multifactorial mental disorder affecting predominantly young females. This systematic review examines neuroimaging findings in adolescents and young adults up to 24 years old, in order to explore alterations associated with disease pathophysiology.
methodsEligible studies on structural and functional brain neuroimaging were sought systematically in PubMed, CENTRAL and EMBASE databases up to 5 October 2020.
resultsThirty-three studies were included, investigating a total of 587 patients with a current diagnosis of AN and 663 healthy controls (HC). Global and regional grey matter (GM) volume reduction as well as white matter (WM) microstructure alterations were detected. The mainly affected regions were the prefrontal, parietal and temporal cortex, hippocampus, amygdala, insula, thalamus and cerebellum as well as various WM tracts such as corona radiata and superior longitudinal fasciculus (SLF). Regarding functional imaging, alterations were pointed out in large-scale brain networks, such as default mode network (DMN), executive control network (ECN) and salience network (SN). Most findings appear to reverse after weight restoration. Specific limitations of neuroimaging studies in still developing individuals are also discussed.
conclusionsStructural and functional alterations are present in the early course of the disease, most of them being partially or totally reversible. Nonetheless, neuroimaging findings have been open to many biological interpretations. Thus, more studies are needed to clarify their clinical significance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.