Evidence map›Paper›PMID 33673171›Full record

ArticleBrain sciences2021

Investigating the Intervention Parameters of Endogenous Paired Associative Stimulation (ePAS).

Gemma Alder, Nada Signal, Alain C Vandal, Sharon Olsen, Mads Jochumsen, Imran Khan Niazi, Denise Taylor

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Gemma AlderHealth and Rehabilitation Research Institute, Auckland University of Technology, Auckland 0627, New Zealand.
Nada SignalHealth and Rehabilitation Research Institute, Auckland University of Technology, Auckland 0627, New Zealand.ORCID 0000-0001-9595-0532
Alain C VandalDepartment of Statistics, University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0002-3153-2953
Sharon OlsenHealth and Rehabilitation Research Institute, Auckland University of Technology, Auckland 0627, New Zealand.ORCID 0000-0002-7453-9127
Mads JochumsenDepartment of Health Science and Technology, Aalborg University, 9000 Aalborg, Denmark.ORCID 0000-0001-7729-4359
Imran Khan NiaziHealth and Rehabilitation Research Institute, Auckland University of Technology, Auckland 0627, New Zealand.ORCID 0000-0001-8752-7224
Denise TaylorHealth and Rehabilitation Research Institute, Auckland University of Technology, Auckland 0627, New Zealand.ORCID 0000-0002-0955-5702
Auckland University of Technology · NZAalborg University · DKNew Zealand College of Chiropractic · NZUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in our understanding of neural plasticity have prompted the emergence of neuromodulatory interventions, which modulate corticomotor excitability (CME) and hold potential for accelerating stroke recovery. Endogenous paired associative stimulation (ePAS) involves the repeated pairing of a single pulse of peripheral electrical stimulation (PES) with endogenous movement-related cortical potentials (MRCPs), which are derived from electroencephalography. However, little is known about the optimal parameters for its delivery. A factorial design with repeated measures delivered four different versions of ePAS, in which PES intensities and movement type were manipulated. Linear mixed models were employed to assess interaction effects between PES intensity (suprathreshold (Hi) and motor threshold (Lo)) and movement type (Voluntary and Imagined) on CME. ePAS interventions significantly increased CME compared to control interventions, except in the case of Lo-Voluntary ePAS. There was an overall main effect for the Hi-Voluntary ePAS intervention immediately post-intervention (

Indexed as

factorial designlinear mixed regressionmovement-related cortical potentialneural plasticityneuromodulationpaired associative stimulationrehabilitation (MeSH)stroke (MeSH)

Identifiers

PMID33673171
PMCPMC7918620
OpenAlexW3133038454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.