Evidence map›Paper›PMID 33673152›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against

Fátima Cerqueira, Marta Maia, Carla Gabriel, Rui Medeiros, Sara Cravo, Ana Isabel Ribeiro, Daniela Dantas, Alice Maria Dias, Lucília Saraiva, Liliana Raimundo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Isobavachalcone effectively inhibits the growth ofAntimicrobial agents and chemotherapy · 2026
    Article
  4. Article
  5. Article
  6. A Cyclam Salt as an Antifungal Agent: Interference withAntibiotics (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Antifungal Activity of a Library of Aminothioxanthones.Antibiotics (Basel, Switzerland) · 2022
    Article
  11. A Review of the Biological Activity of Amidrazone Derivatives.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Fátima CerqueiraHealth Sciences Faculty, University Fernando Pessoa, 4200-150 Porto, Portugal.
Marta MaiaLaboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, 4050-313 Porto, Portugal.
Carla GabrielHealth Sciences Faculty, University Fernando Pessoa, 4200-150 Porto, Portugal.
Rui MedeirosHealth Sciences Faculty, University Fernando Pessoa, 4200-150 Porto, Portugal.ORCID 0000-0003-3010-8373
Sara CravoInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, 4450-208 Matosinhos, Portugal.ORCID 0000-0001-9314-8669
Ana Isabel RibeiroCentre of Chemistry, Department of Chemistry, University of Minho, 4710-057 Braga, Portugal.
Daniela DantasCentre of Chemistry, Department of Chemistry, University of Minho, 4710-057 Braga, Portugal.
Alice Maria DiasCentre of Chemistry, Department of Chemistry, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-5111-0774
Lucília SaraivaLAQV/REQUIMTE, Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-9531-4939
Liliana RaimundoLAQV/REQUIMTE, Laboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, 4050-313 Porto, Portugal.
Eugénia PintoInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, 4450-208 Matosinhos, Portugal.ORCID 0000-0003-2948-5809
Universidade do Porto · PTFernando Pessoa University · PTUniversity of Minho · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic mycoses are one major cause of morbidity/mortality among immunocompromised/debilitated individuals. Studying the mechanism of action is a strategy to develop safer/potent antifungals, warning resistance emergence. The major goal of this study was to elucidate the mechanism of action of three (

Indexed as

antifungalsCandida sp.dimorphic transitionergosterolmechanisms of actionmetabolic viabilityreactive oxygen species(Z)-5-amino-N’-aryl-1-methyl-1H-imidazole-4-carbohydrazonamides

Identifiers

PMID33673152
PMCPMC7917925
OpenAlexW3132529717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.