Evidence map›Paper›PMID 33673111›Full record

ArticlePharmacy (Basel, Switzerland)2021

Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation.

Tracey Thornley, Bernard Esquivel, David J Wright, Hidde van den Dop, Charlotte L Kirkdale, Essra Youssef

Abstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  12. The Implementation of Pharmacogenetics in the United Kingdom.Handbook of experimental pharmacology · 2023
    Article
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  14. Article
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  17. Moving Pharmacogenetics Into Practice: It's All About the Evidence!Clinical pharmacology and therapeutics · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tracey ThornleyBoots UK, Thane Road, Nottingham NG90 1BS, UK.
Bernard EsquivelOneOme, 807 Broadway St. NE, Suite 100, Minneapolis, MN 55413, USA.
David J WrightUniversity of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.ORCID 0000-0003-3690-9593
Hidde van den DopAlliance Healthcare, De Amert 603, 5462 GH Veghel, The Netherlands.
Charlotte L KirkdaleBoots UK, Thane Road, Nottingham NG90 1BS, UK.
Essra YoussefUniversity of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Community pharmacy services have evolved to include medical and pharmaceutical interventions alongside dispensing. While established pharmacogenomic (PGx) testing is available throughout the Netherlands, this is primarily based in hospital environments and for specialist medicines. The aim of this work was to describe how best to implement PGx services within community pharmacy, considering potential barriers and enablers to service delivery and how to address them. The service was implemented across a selection of community pharmacies in the Netherlands. Data were captured on test outcomes and through a pharmacist survey. Following testing, 17.8% of the clinical samples were recommended to avoid certain medication (based on their current medicines use), and 14.0% to have their dose adjusted. Pre-emptive analysis of genotyped patients showed that the majority (99.2%) had actionable variants. Pharmacists felt confident in their operational knowledge to deliver the service, but less so in applying that knowledge. Delivering the service was believed to improve relationships with other healthcare professionals. These results add to the evidence in understanding how PGx can be delivered effectively within the community pharmacy environment. Training pharmacists in how to respond to patient queries and make clinical recommendations may enhance service provision further.

Indexed as

community pharmacyimplementationmedicines optimizationpharmacogenomics

Identifiers

PMID33673111
PMCPMC7930936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.