Evidence map›Paper›PMID 33672989›Full record

ArticleInternational journal of molecular sciences2021

Bi-Functional Radiotheranostics of

Yi-Shu Huang, Wei-Chuan Hsu, Chien-Hong Lin, Sheng-Nan Lo, Chu-Nian Cheng, Ming-Syuan Lin, Te-Wei Lee, Chih-Hsien Chang, Keng-Li Lan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Translating Research for the Radiotheranostics of NanotargetedInternational journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yi-Shu HuangDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Wei-Chuan HsuDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Chien-Hong LinDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Sheng-Nan LoDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Chu-Nian ChengDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Ming-Syuan LinDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Te-Wei LeeDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Chih-Hsien ChangDivision of Isotope Application, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.
Keng-Li LanDepartment of Oncology, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Institute of Nuclear Energy Research · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR) specific therapeutics is of great importance in cancer treatment. Fcy-hEGF fusion protein, composed of yeast cytosine deaminase (Fcy) and human EGF (hEGF), is capable of binding to EGFR and enzymatically convert 5-fluorocytosine (5-FC) to 1000-fold toxic 5-fluorocuracil (5-FU), thereby inhibiting the growth of EGFR-expressing tumor cells. To develop EGFR-specific therapy,

Indexed as

Antimetabolites, AntineoplasticCell Line, TumorCell SurvivalCytosine DeaminaseEpidermal Growth FactorErbB ReceptorsFlucytosineFluorouracilHumansLiposomesMCF-7 CellsNeoplasmsProtein BindingRadioisotopesRadiopharmaceuticalsRheniumAntimetabolites, AntineoplasticCytosine DeaminaseEpidermal Growth FactorErbB ReceptorsFlucytosineFluorouracilLiposomesRadioisotopesRadiopharmaceuticalsRheniumRhenium-1885-fluorocuracilcytosine deaminaseepidermal growth factor receptorliposomeprodrugrhenium-188

Identifiers

PMID33672989
PMCPMC7918434
OpenAlexW3132762909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.