Evidence map›Paper›PMID 33672967›Full record

ArticleNutrients2021

Upregulation of Vitamin C Transporter Functional Expression in 5xFAD Mouse Intestine.

Trevor Teafatiller, Christopher W Heskett, Anshu Agrawal, Jonathan S Marchant, Janet E Baulch, Munjal M Acharya, Veedamali S Subramanian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The multifaceted roles of the transcription factorAlzheimer's & dementia (New York, N. Y.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Trevor TeafatillerDepartment of Medicine, University of California, Irvine, CA 92697, USA.
Christopher W HeskettDepartment of Medicine, University of California, Irvine, CA 92697, USA.
Anshu AgrawalDepartment of Medicine, University of California, Irvine, CA 92697, USA.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Janet E BaulchDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Munjal M AcharyaDepartment of Radiation Oncology, University of California, Irvine, CA 92697, USA.
Veedamali S SubramanianDepartment of Medicine, University of California, Irvine, CA 92697, USA.
University of California, Irvine · USMedical College of Wisconsin · US

Funding

NIH HHS DK107474
6 · The paper itself

Abstract

The process of obtaining ascorbic acid (AA) via intestinal absorption and blood circulation is carrier-mediated utilizing the AA transporters SVCT1 and SVCT2, which are expressed in the intestine and brain (SVCT2 in abundance). AA concentration is decreased in Alzheimer's disease (AD), but information regarding the status of intestinal AA uptake in the AD is still lacking. We aimed here to understand how AA homeostasis is modulated in a transgenic mouse model (5xFAD) of AD. AA levels in serum from 5xFAD mice were markedly lower than controls. Expression of oxidative stress response genes (glutathione peroxidase 1 (GPX1) and superoxide dismutase 1 (SOD1)) were significantly increased in AD mice jejunum, and this increase was mitigated by AA supplementation. Uptake of AA in the jejunum was upregulated. This increased AA transport was caused by a marked increase in SVCT1 and SVCT2 protein, mRNA, and heterogeneous nuclear RNA (hnRNA) expression. A significant increase in the expression of HNF1α and specific protein 1 (Sp1), which drive SLC23A1 and SLC23A2 promoter activity, respectively, was observed. Expression of hSVCT interacting proteins GRHPR and CLSTN3 were also increased. SVCT2 protein and mRNA expression in the hippocampus of 5xFAD mice was not altered. Together, these investigations reveal adaptive up-regulation of intestinal AA uptake in the 5xFAD mouse model.

Indexed as

Alcohol OxidoreductasesAlzheimer DiseaseAnimalsAscorbic AcidBiological TransportCalcium-Binding ProteinsDietary SupplementsDisease Models, AnimalGlutathione PeroxidaseGlutathione Peroxidase GPX1Hepatocyte Nuclear Factor 1-alphaHippocampusHomeostasisIntestinal AbsorptionJejunumMembrane ProteinsAlcohol OxidoreductasesAscorbic AcidCalcium-Binding ProteinsClstn3 protein, mouseGlutathione PeroxidaseGlutathione Peroxidase GPX1glyoxylate reductaseGpx1 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseMembrane ProteinsRNA, MessengerSod1 protein, mouseSodium-Coupled Vitamin C TransportersSuperoxide Dismutase-1Alzheimer’s diseaseSVCT1SVCT2transportVitamin C

Identifiers

PMID33672967
PMCPMC7918291
OpenAlexW3131085773

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.