ArticleLife (Basel, Switzerland)2021
Correlation of the ALA-PDT Treatment Efficacy and the HPV Genotype Profile of Genital Warts after Cryotherapy Failure and Podophyllotoxin Therapy in Male Patients.
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The impact of photodynamic therapy on cellular immune function in patients with cervical HPV infection.Clinics (Sao Paulo, Brazil) · 2025Trial
- Photodynamic Therapy Efficacy of the Human Papillomavirus-Related Cervical Lesions.Journal of clinical medicine · 2026Article
- Evaluation of efficacy and optimal therapeutic parameters of ALA-PDT in the management of HPV-associated cervical intraepithelial neoplasia grade I.Frontiers in oncology · 2026Article
- Evaluation of HPV infection and presence of licensed HPV vaccine genotypes among genital warts in Foshan, China.Frontiers in microbiology · 2024Article
- Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment.Inflammation and regeneration · 2022Review
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenital warts are the manifestation of the human papillomavirus (HPV) infection, which may last for weeks or months before the clinical presentation. The primary aim of the study was the correlation of the DNA HPV genotypes eradication with the treatment response in male patients with persistent genital warts.
methodsTwenty-one male patients (age range: 22-58) after failure of cryotherapy and podophyllotoxin treatment were enrolled in the study. Genetic tests (Real Time - PCR method) analyzed the presence of DNA-HPV before and 6 months after four sessions (4 weeks apart) of photodynamic therapy with 5-aminolaevulinic acid (ALA-PDT). The treatment efficacy was evaluated before each PDT session and at the end of the study.
resultsThe single HPV DNA type was present in 15/21 of the patients (13/15 HPV6). The high-risk HPV types were found in 8/21 subjects, of which 6/8 had several types. Six months after four sessions of PDT, complete response was found in 16/21 (76.19%;
conclusionALA-PDT is an effective treatment even after the failure of previous modalities. The persistence of clinical lesions and high oncological risk HPV types should be an indication for treatment prolongation.
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