Evidence map›Paper›PMID 33672815›Full record

ArticleCancers2021

Second Relapse of Pediatric Patients with Acute Myeloid Leukemia: A Report on Current Treatment Strategies and Outcome of the AML-BFM Study Group.

Mareike Rasche, Emma Steidel, Martin Zimmermann, Jean-Pierre Bourquin, Heidrun Boztug, Iveta Janotova, E Anders Kolb, Thomas Lehrnbecher, Nils von Neuhoff, Naghmeh Niktoreh and 7 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mareike RascheDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, 45147 Essen, Germany.ORCID 0000-0002-7687-3655
Emma SteidelDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, 45147 Essen, Germany.
Martin ZimmermannDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Jean-Pierre BourquinDivision of Pediatric Hematology/Oncology, University Children's Hospital Zurich, CH-8032 Zurich, Switzerland.
Heidrun BoztugSt Anna Children's Hospital and Children's Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Iveta JanotovaDepartment of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic.
E Anders KolbNemours/Alfred I. du Pont Hospital for Children, Wilmington, DE 19803, USA.
Thomas LehrnbecherDivision for Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, 60590 Frankfurt, Germany.
Nils von NeuhoffDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, 45147 Essen, Germany.ORCID 0000-0003-4138-5341
Naghmeh NiktorehDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, 45147 Essen, Germany.ORCID 0000-0002-5032-4789
Nora MühleggerSt Anna Children's Hospital and Children's Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Lucie SramkovaDepartment of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic.
Jan StaryDepartment of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic.
Christiane WalterDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, 45147 Essen, Germany.ORCID 0000-0002-7832-895X
Ursula CreutzigDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Michael DworzakSt Anna Children's Hospital and Children's Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Dirk ReinhardtDepartment of Pediatric Hematology-Oncology, Pediatrics III, University Hospital of Essen, 45147 Essen, Germany.ORCID 0000-0002-7027-4483

Funding

Deutsche Krebshilfe 50-2728, 110244
6 · The paper itself

Abstract

Successful management of relapse is critical to improve outcomes of children with acute myeloid leukemia (AML). We evaluated response, survival and prognostic factors after a second relapse of AML. Among 1222 pediatric patients of the population-based AML-Berlin-Frankfurt-Munster (BFM) study group (2004 until 2017), 73 patients met the quality parameters for inclusion in this study. Central review of source documentation warranted the accuracy of reported data. Treatment approaches included palliation in 17 patients (23%), intensive therapy with curative intent (

Indexed as

acute myeloid leukemiachildhood acute myeloid leukemiapediatricrelapsesalvage therapy

Identifiers

PMID33672815
PMCPMC7918758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.