Evidence map›Paper›PMID 33672789›Full record

ArticleInternational journal of molecular sciences2021

Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.

Shin Hamada, Ryotaro Matsumoto, Yu Tanaka, Keiko Taguchi, Masayuki Yamamoto, Atsushi Masamune

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

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  11. Small molecule inhibitors for cancer metabolism: promising prospects to be explored.Journal of cancer research and clinical oncology · 2023
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  20. Role of Nrf2 in Pancreatic Cancer.Antioxidants (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shin HamadaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
Ryotaro MatsumotoDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
Yu TanakaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
Keiko TaguchiDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.ORCID 0000-0002-5798-0076
Masayuki YamamotoDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
Tohoku University · JP

Funding

Japan Society for the Promotion of Science 19H03631Japan Society for the Promotion of Science 20K08300Smoking Research Foundation to Shin Hamada
6 · The paper itself

Abstract

Pancreatic cancer remains intractable owing to the lack of effective therapy for unresectable cases. Activating mutations of

Indexed as

MutationAnimalsBenzeneacetamidesCell Line, TumorCell SurvivalGene Expression Regulation, NeoplasticGlutaminaseHumansKelch-Like ECH-Associated Protein 1MalatesMiceMice, KnockoutMice, TransgenicNF-E2-Related Factor 2Pancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Benzeneacetamidesbis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfideCB-839diethyl malateGlutaminaseHras protein, mouseKelch-Like ECH-Associated Protein 1MalatesNfe2l2 protein, mouseNF-E2-Related Factor 2Proto-Oncogene Proteins p21(ras)SulfidesThiadiazolesBPTESCB-839glutaminaseKeap1Nrf2

Identifiers

PMID33672789
PMCPMC7918355
OpenAlexW3129896649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.