Evidence map›Paper›PMID 33672715›Full record

ArticleToxins2021

Novel Three-Finger Neurotoxins from

Lina Son, Elena Kryukova, Rustam Ziganshin, Tatyana Andreeva, Denis Kudryavtsev, Igor Kasheverov, Victor Tsetlin, Yuri Utkin

Open access · goldAbstract readComparative Study
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Pharmacological Screening of Venoms from Five BrazilianInternational journal of molecular sciences · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lina SonShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Elena KryukovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Rustam ZiganshinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Tatyana AndreevaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Denis KudryavtsevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.ORCID 0000-0002-0313-9193
Igor KasheverovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.ORCID 0000-0002-7373-6524
Victor TsetlinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.ORCID 0000-0002-7980-6191
Yuri UtkinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.ORCID 0000-0002-4609-970X
Institute of Bioorganic Chemistry · RUMoscow Institute of Physics and Technology · RUSechenov University · RU

Funding

Russian Foundation for Basic Research 18-04-01075
6 · The paper itself

Abstract

Cobra venoms contain three-finger toxins (TFT) including α-neurotoxins efficiently binding nicotinic acetylcholine receptors (nAChRs). As shown recently, several TFTs block GABA

Indexed as

Najaalpha7 Nicotinic Acetylcholine ReceptorAnimalsBinding, CompetitiveBinding SitesCell Line, TumorCholinergic AgentsCobra Neurotoxin ProteinsElapid VenomsGABA-A Receptor AntagonistsMembrane PotentialsMiceProtein BindingProtein ConformationReceptors, GABAStructure-Activity Relationshipalpha7 Nicotinic Acetylcholine Receptoralpha-cobratoxinCholinergic AgentsCobra Neurotoxin ProteinsElapid VenomsGABA-A Receptor AntagonistsReceptors, GABAacetylcholine binding proteinbinding sitescobra venomGABAA receptorneurotoxinnicotinic acetylcholine receptorthree-finger toxin

Identifiers

PMID33672715
PMCPMC7924340
OpenAlexW3132526465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.