Evidence map›Paper›PMID 33672695›Full record

ArticleInternational journal of molecular sciences2021

Effects of Irregular Feeding on the Daily Fluctuations in mRNA Expression of the Neurosecretory Protein GL and Neurosecretory Protein GM Genes in the Mouse Hypothalamus.

Atsuki Kadota, Eiko Iwakoshi-Ukena, Keisuke Fukumura, Kenshiro Shikano, Yuki Narimatsu, Megumi Furumitsu, Kazuyoshi Ukena

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Atsuki KadotaLaboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
Eiko Iwakoshi-UkenaLaboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
Keisuke FukumuraLaboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
Kenshiro ShikanoLaboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
Yuki NarimatsuLaboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
Megumi FurumitsuLaboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.
Kazuyoshi UkenaLaboratory of Neurometabolism, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8521, Japan.ORCID 0000-0003-0942-6035

Funding

Japan Society for the Promotion of Science JP18K19743Japan Society for the Promotion of Science JP19H03258Japan Society for the Promotion of Science JP19K06768Japan Society for the Promotion of Science JP20H03296Japan Society for the Promotion of Science JP20K21760Japan Society for the Promotion of Science JP20K22741the ONO Medical Research Foundation nonethe Takeda Science Foundation nonethe Uehara Memorial Foundation none
6 · The paper itself

Abstract

Circadian desynchrony induced by a long period of irregular feeding leads to metabolic diseases, such as obesity and diabetes mellitus. The recently identified neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM) are hypothalamic small proteins that stimulate food intake and fat accumulation in several animals. To clarify the mechanisms that evoke feeding behavior and induce energy metabolism at the appropriate times in accordance with a circadian rhythm, diurnal fluctuations in

Indexed as

Gene Expression RegulationAnalysis of VarianceAnimalsAnorexiaBlood GlucoseCLOCK ProteinsFeeding BehaviorGene Expression ProfilingHypothalamusInsulinLipid MetabolismMaleMiceMice, Inbred C57BLNerve Tissue ProteinsOrexinsBlood GlucoseCLOCK ProteinsInsulinNerve Tissue Proteinsneurosecretory protein GL, mouseNPGM protein, mouseOrexinsRNA, Messengerenvironmental light/dark cyclefat accumulationfeeding restrictionfood intakeneurosecretory protein GLneurosecretory protein GMrhythmicity

Identifiers

PMID33672695
PMCPMC7924315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.