ReviewAntibiotics (Basel, Switzerland)2021
The Antimicrobial Effect of Cold Atmospheric Plasma against Dental Pathogens-A Systematic Review of In-Vitro Studies.
Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The Effectiveness of Cold Atmospheric Plasma (CAP) on Bacterial Reduction in Dental Implants: A Systematic Review.Biomolecules · 2023Pooled it
- 1064 nm Nd:YAG versus 940 nm diode laser-assisted periodontal therapy in stage II periodontitis: a randomized controlled trial.BMC oral health · 2026Trial
- Effects of a cold atmospheric plasma device utilizing ambient air on bracket bonding to human enamel and surface roughness after debonding.Clinical oral investigations · 2026Article
- Non-Invasive Physical Plasma Regulates COX-2 via EP2/EP4 Expression in Periodontal Ligament Cells Under Inflammatory Conditions.International journal of molecular sciences · 2026Article
- Cold atmospheric plasma for implant surface decontamination and osseointegration: a scoping review with implications for peri-implantitis management.BMC oral health · 2026Article
- Cold Atmospheric Plasma in Pediatric Dentistry: A Paradigm Shift toward Antibiotic-free Minimally Invasive Care.International journal of clinical pediatric dentistry · 2026Review
- Cold Atmospheric Plasma in Biomedicine and Pharmacology: Multidisciplinary Perspectives on Therapeutic Applications.ACS pharmacology & translational science · 2026Review
- Plasma-activated water: a dual-action disinfectant and wound-healing therapy for diabetes-related foot infections.FEMS microbiology reviews · 2026Review
- Efficacy and Safety of Cold Atmospheric Pressure Plasma in Dental Practice: A Systematic Review of Preclinical and Clinical Evidence.International journal of dentistry · 2026Review
- Beyond Conventional Disinfectants: A Comparative Review of Cold Atmospheric Plasma and Photodynamic Therapy against Oral Pathogens.Journal of lasers in medical sciences · 2026Review
- Advances in cold atmospheric plasma therapy for cancer.Bioactive materials · 2025Review
- Clinical Evaluation of Underwater Discharge Plasma as a Root Canal Irrigant: A Randomized Pilot Study on Efficacy and Safety.Biomedicines · 2025Article
- Cold-Plasma Method in Counteracting Prosthetic Stomatitis: Analysis of the Influence of Cold Plasma on Prosthetic Materials.Materials (Basel, Switzerland) · 2025Article
- The Effect of Dielectric Barrier Discharge Plasma onJournal of lasers in medical sciences · 2025Article
- Effectiveness of cold atmospheric plasma in decontaminating enterococcus faecalis colonized collagen and PTFE membranes used in guided bone regeneration: a comparative in vitro investigation.International journal of implant dentistry · 2024Article
- Impact of DBD Plasma Jet Treatment on the Enamel Surface of Primary Teeth.Materials (Basel, Switzerland) · 2024Article
- Exploring the efficacy of in-vitro low-temperature plasma treatment on single and multispecies dental cariogenic biofilms.Scientific reports · 2024Article
- Anti-Inflammatory Activity of No-Ozone Cold Plasma inInternational journal of molecular sciences · 2024Article
- Influence of Biofilm Maturity on the Antibacterial Efficacy of Cold Atmospheric Plasma in Oral Microcosm Biofilms.Biomedicines · 2024Article
- Cold plasma for enhanced water purification.Sustainable microbiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interest in the application of cold atmospheric plasma (CAP) in the medical field has been increasing. Indications in dentistry are surface modifications and antimicrobial interventions. The antimicrobial effect of CAP is mainly attributed to the generation of reactive oxygen and reactive nitrogen species. The aim of this article is to systematically review the available evidence from in-vitro studies on the antimicrobial effect of CAP on dental pathogens. A database search was performed (PubMed, Embase, Scopus). Data concerning the device parameters, experimental set-ups and microbial cultivation were extracted. The quality of the studies was evaluated using a newly designed assessment tool. 55 studies were included (quality score 31-92%). The reduction factors varied strongly among the publications although clusters could be identified between groups of set pathogen, working gases, and treatment time intervals. A time-dependent increase of the antimicrobial effect was observed throughout the studies. CAP may be a promising alternative for antimicrobial treatment in a clinically feasible application time. The introduced standardized protocol is able to compare the outcome and quality of in-vitro studies. Further studies, including multi-species biofilm models, are needed to specify the application parameters of CAP before CAP should be tested in randomized clinical trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.