Evidence map›Paper›PMID 33672679›Full record

ArticleCells2021

Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients.

Jue Wang, Laura Hertz, Sandra Ruppenthal, Wassim El Nemer, Philippe Connes, Jeroen S Goede, Anna Bogdanova, Lutz Birnbaumer, Lars Kaestner

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Increased Susceptibility for Adverse Reactions to Ultrasound Enhancing Agents in Sickle Cell Disease.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023
    Article
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 5 countries.

Jue WangDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
Laura HertzTheoretical Medicine and Biosciences, Saarland University, 66421 Homburg, Germany.
Sandra RuppenthalExperimental Physics, Dynamics of Fluids, Saarland University, 66123 Saarbrücken, Germany.
Wassim El NemerEtablissement Français du Sang PACA-Corse, Aix Marseille Université, EFS, CNRS, ADES, 13005 Marseille, France.ORCID 0000-0001-8184-427X
Philippe ConnesLaboratoire d'Excellence GR-Ex, 75015 Paris, France.ORCID 0000-0002-9232-0268
Jeroen S GoedeDivision of Oncology and Hematology, Kantonsspital Winterthur, CH-8401 Winterthur, Switzerland.
Anna BogdanovaRed Blood Cell Research Group, Institute of Veterinary Physiology, University of Zürich, CH-8057 Zürich, Switzerland.ORCID 0000-0003-0502-5381
Lutz BirnbaumerInstitute of Biomedical Research (BIOMED), Catholic University of Argentina, C1107AFF Buenos Aires, Argentina.
Lars KaestnerTheoretical Medicine and Biosciences, Saarland University, 66421 Homburg, Germany.
Saarland University · DECentre National de la Recherche Scientifique · FRKantonsspital Winterthur · CHPontificia Universidad Católica Argentina · ARThe University of Texas Health Science Center at Tyler · USUniversité Claude Bernard Lyon 1 · FRUniversity of Zurich · CH

Funding

Transmembrane Signaling MechanismsZ01ES101643 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$5.1M
Intramural NIH HHS Z01 ES101643
6 · The paper itself

Abstract

(1) Background: It is known that sickle cells contain a higher amount of Ca

Indexed as

Calcium SignalingAnemia, Sickle CellAnimalsCalciumCalcium Channels, N-TypeErythrocytesGTP-Binding ProteinsHeLa CellsHumansLysophospholipidsMAP Kinase Signaling SystemMiceModels, BiologicalProtein Kinase CTissue DonorsTRPC6 Cation ChannelCalciumCalcium Channels, N-TypeGTP-Binding Proteinslysophosphatidic acidLysophospholipidsProtein Kinase CTRPC6 Cation ChannelTRPC6 protein, humanCaV2.1erythrocytesGárdos channelG protein signalingLPA receptorMAP kinaseprotein kinase Cαsickle cell diseasetransgenic miceTRPC6

Identifiers

PMID33672679
PMCPMC7924404
OpenAlexW3130420883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.