Evidence map›Paper›PMID 33672677›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Rapid Methods for Antimicrobial Resistance Diagnostics.

Georgia D Kaprou, Ieva Bergšpica, Elena A Alexa, Avelino Alvarez-Ordóñez, Miguel Prieto

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 175 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Georgia D KaprouDepartment of Food Hygiene and Technology, University of León, 24071 León, Spain.
Ieva BergšpicaDepartment of Food Hygiene and Technology, University of León, 24071 León, Spain.
Elena A AlexaDepartment of Food Hygiene and Technology, University of León, 24071 León, Spain.ORCID 0000-0003-2833-2552
Avelino Alvarez-OrdóñezDepartment of Food Hygiene and Technology, University of León, 24071 León, Spain.
Miguel PrietoDepartment of Food Hygiene and Technology, University of León, 24071 León, Spain.ORCID 0000-0001-9202-3856
Universidad de León · ESInstitute of Food Safety, Animal Health and Environment “BIOR” · LVUniversity of Luxembourg · LU

Funding

European Food Safety Authority EU-FORA Fellowship Programme 2019-2020Ministerio de Ciencia, Innovación y Universidades AGL2016-78085-P
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is one of the most challenging threats in public health; thus, there is a growing demand for methods and technologies that enable rapid antimicrobial susceptibility testing (AST). The conventional methods and technologies addressing AMR diagnostics and AST employed in clinical microbiology are tedious, with high turnaround times (TAT), and are usually expensive. As a result, empirical antimicrobial therapies are prescribed leading to AMR spread, which in turn causes higher mortality rates and increased healthcare costs. This review describes the developments in current cutting-edge methods and technologies, organized by key enabling research domains, towards fighting the looming AMR menace by employing recent advances in AMR diagnostic tools. First, we summarize the conventional methods addressing AMR detection, surveillance, and AST. Thereafter, we examine more recent non-conventional methods and the advancements in each field, including whole genome sequencing (WGS), matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) spectrometry, Fourier transform infrared (FTIR) spectroscopy, and microfluidics technology. Following, we provide examples of commercially available diagnostic platforms for AST. Finally, perspectives on the implementation of emerging concepts towards developing paradigm-changing technologies and methodologies for AMR diagnostics are discussed.

Indexed as

antibiotic susceptibility testingantimicrobial resistanceFTIRlab-on-a-chipMALDI-TOFmicrofluidicsmolecular diagnosticspoint-of-caresequencing

Identifiers

PMID33672677
PMCPMC7924329
OpenAlexW3131007698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.