Evidence map›Paper›PMID 33672606›Full record

ArticleInternational journal of molecular sciences2021

Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson's Disease Model.

Seulah Lee, Yeon Ji Suh, Seonguk Yang, Dong Geun Hong, Akihito Ishigami, Hangun Kim, Jae-Seoun Hur, Seung-Cheol Chang, Jaewon Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

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  4. Phytochemical combinations of lichenFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Seulah LeeDepartment of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Yeon Ji SuhDepartment of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Seonguk YangDepartment of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Dong Geun HongDepartment of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Akihito IshigamiMolecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.ORCID 0000-0001-7875-7482
Hangun KimCollege of Pharmacy, Sunchon National University, Suncheon 57922, Korea.
Jae-Seoun HurKorean Lichen Research Institute, Sunchon National University, Suncheon 57922, Korea.ORCID 0000-0001-8547-7075
Seung-Cheol ChangDepartment of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan 46241, Korea.ORCID 0000-0002-2333-9424
Jaewon LeeDepartment of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.ORCID 0000-0003-3203-2130
Pusan National University · KRSunchon National University · KRTokyo Metropolitan Institute of Gerontology · JP

Funding

National Research Foundation of Korea 2018R1D1A1B07043493National Research Foundation of Korea 2019H1A2A1076083
6 · The paper itself

Abstract

Oxidative stress, mitochondrial dysfunction, and neuroinflammation are strongly associated with the pathogenesis of Parkinson's disease (PD), which suggests that anti-oxidative and anti-inflammatory compounds might provide an alternative treatment for PD. Here, we evaluated the neuroprotective effects of evernic aid (EA), which was screened from a lichen library provided by the Korean Lichen Research Institute at Sunchon National University. EA is a secondary metabolite generated by lichens, including

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAnti-Inflammatory AgentsApoptosisAstrocytesCells, CulturedDisease Models, AnimalDopaminergic NeuronsDrug Evaluation, PreclinicalHydroxybenzoatesLichensMaleMiceMice, Inbred C57BLMitochondriaMotor Activity1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnti-Inflammatory Agentsevernic acidHydroxybenzoatesNeuroprotective AgentsNF-kappa B1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineanti-inflammationevernic acidneuroinflammationneuroprotectionParkinson’s disease

Identifiers

PMID33672606
PMCPMC7924051
OpenAlexW3130562781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.