ArticleFoods (Basel, Switzerland)2021
Angiotensin-I Converting Enzyme Inhibition and Antioxidant Activity of Papain-Hydrolyzed Camel Whey Protein and Its Hepato-Renal Protective Effects in Thioacetamide-Induced Toxicity.
Article in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Evaluation of prophylactic and therapeutic activity of camel whey protein and its trypsinized hydrolysate against experimental trichinellosis.BMC complementary medicine and therapies · 2025Article
- Investigating the impact of camel whey protein hydrolysate on cyp1a1 and keap1/nrf2 expression in hypoxic stress-affected liver tissue of Oreochromis niloticus.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Whey Proteins and Bioactive Peptides: Advances in Production, Selection and Bioactivity Profiling.Biomedicines · 2025Review
- Carbonate alkalinity induces stress responses and renal and metabolic disorders in Nile tilapia: mitigation by camel whey protein hydrolysate diet.Fish physiology and biochemistry · 2025Article
- Unraveling the Biological Properties of Whey Peptides and Their Role as Emerging Therapeutics in Immune Tolerance.Nutrients · 2025Review
- Effect of fish meal substitution with trout viscera protein hydrolysate on the innate immune response of red tilapia (Oreochromis spp).Fish physiology and biochemistry · 2025Article
- Ameliorative role of camel protein hydrolysates diet against alkaline stress in Oreochrmis niloticus: Hematology, immune responses and their regulating genes expression, and histopathological assays.Veterinary research communications · 2025Article
- In Silico Hydrolysis of Lupin (International journal of molecular sciences · 2024Article
- Unveiling the Potential of Silymarin,Life (Basel, Switzerland) · 2024Article
- Green synthesis, characterization, and hepatoprotective effect of zinc oxide nanoparticles fromHeliyon · 2024Article
- The ameliorating role of sofosbuvir and daclatasvir on thioacetamide-induced kidney injury in adult albino rats.Anatomy & cell biology · 2023Article
- The Ameliorate Effects of Nerolidol on Thioacetamide-induced Oxidative Damage in Heart and Kidney TissueTurkish journal of pharmaceutical sciences · 2022Article
- Camel milk protectiveness toward multiple liver disorders: A review.Frontiers in nutrition · 2022Review
- Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats.Saudi journal of biological sciences · 2022Article
- High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products.Molecules (Basel, Switzerland) · 2021Article
- Physiological Performance of Rabbits Administered Buffalo Milk Yogurts Enriched with Whey Protein Concentrate, Calcium Caseinate orFoods (Basel, Switzerland) · 2021Article
- Cocoa (Foods (Basel, Switzerland) · 2021Article
- Activation of the Peroxisome Proliferator-Activated Receptors (PPAR-PPAR research · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papain hydrolysis of camel whey protein (CWP) produced CWP hydrolysate (CWPH). Fractionation of CWPH by the size exclusion chromatography (SEC) generated fractions (i.e., SEC-F1 and SEC-F2). The angiotensin converting enzyme inhibitory activity (ACE-IA) and free radical scavenging actions were assessed for CWP, CWPH, SEC-F1, and SEC-F2. The SEC-F2 exerted the highest ACE-IA and scavenging activities, followed by CWPH. The protective effects of CWPH on thioacetamide (TAA)-induced toxicity were investigated in rats. The liver enzymes, protein profile, lipid profile, antioxidant enzyme activities, renal functions, and liver histopathological changes were assessed. Animals with TAA toxicity showed impaired hepatorenal functions, hyperlipidemia, and decreased antioxidant capacity. Treatment by CWPH counteracted the TAA-induced oxidative tissue damage as well as preserved the renal and liver functions, the antioxidative enzyme activities, and the lipid profile, compared to the untreated animals. The current findings demonstrate that the ACE-IA and antioxidative effects of CWPH and its SEC-F2 fraction are worth noting. In addition, the CWPH antioxidative properties counteracted the toxic hepatorenal dysfunctions. It is concluded that the hydrolysis of CWP generates a wide range of bioactive peptides with potent antihypertensive, antioxidant, and hepatorenal protective properties. This opens up new prospects for the therapeutic utilization of CWPH and its fractions in the treatment of oxidative stress-associated health problems, e.g., hypertension and hepatorenal failure.
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