Evidence map›Paper›PMID 33672577›Full record

ReviewHealthcare (Basel, Switzerland)2021

Echocardiographic Screening of Anomalous Origin of Coronary Arteries in Athletes with a Focus on High Take-Off

Massimiliano Cantinotti, Raffaele Giordano, Nadia Assanta, Martin Koestenberger, Eliana Franchi, Pietro Marchese, Alberto Clemente, Shelby Kutty, Flavio D'Ascenzi

Open access · goldAbstract readReview
In one paragraph

Review in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Cardiac evaluation of paediatric athletes.European heart journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Massimiliano CantinottiPediatric Cardiology Department, Fondazione CNR-Regione Toscana G. Monasterio, 54100 Massa, Italy.
Raffaele GiordanoDepartment of Advanced Biomedical Sciences, Adult and Pediatric Cardiac Surgery, University of Naples Federico II, 80131 Naples, Italy.
Nadia AssantaPediatric Cardiology Department, Fondazione CNR-Regione Toscana G. Monasterio, 54100 Massa, Italy.
Martin KoestenbergerDepartment of Pediatrics, Division of Pediatric Cardiology, Medical University Graz, 8036 Graz, Austria.ORCID 0000-0003-1766-7859
Eliana FranchiPediatric Cardiology Department, Fondazione CNR-Regione Toscana G. Monasterio, 54100 Massa, Italy.
Pietro MarchesePediatric Cardiology Department, Fondazione CNR-Regione Toscana G. Monasterio, 54100 Massa, Italy.ORCID 0000-0003-4801-608X
Alberto ClementeImaging Department, Fondazione CNR-Regione Toscana G. Monasterio, 54100 Massa, Italy.ORCID 0000-0002-4285-9468
Shelby KuttyTaussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD 21205, USA.
Flavio D'AscenziDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.
Fondazione Toscana Gabriele Monasterio · ITIstituto di Fisiologia Clinica · ITJohns Hopkins Hospital · USMedical University of Graz · ATUniversity of Naples Federico II · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anomalous aortic origin of coronary arteries (AAOCA) represents a rare congenital heart disease. However, this disease is the second most common cause of sudden cardiac death in apparently healthy athletes. The aim of this systematic review is to analyze the feasibility and the detection rate of AAOCA by echocardiography in children and adults. A literature search was performed within the National Library of Medicine using the following keywords: coronary artery origin anomalies and echocardiography; then, the search was redefined by adding the keywords: athletes, children, and high take-off. Nine echocardiographic studies investigating AAOCA and a total of 33,592 children and adults (age range: 12-49 years) were included in this review. Of these, 6599 were athletes (12-49 years). All studies demonstrated a high feasibility and accuracy of echocardiography for the evaluation of coronary arteries origin as well as their proximal tracts. However, some limitations exist: the incidence of AAOCA varied from 0.09% to 0.39% (up to 0.76%) and was lower than described in computed tomography series (0.3-1.8%). Furthermore, echocardiographic views for the evaluation of AAOCA and the definition of "minor" defects (e.g., high take-off coronary arteries) have not been standardized. An echocardiographic protocol to diagnose the high take-off of coronary arteries is proposed in this article. In conclusion, the screening of AAOCA by echocardiography is feasible and accurate when appropriate examinations are performed; however, specific acoustic windows and definitions of defects other than AAOCA need to be standardized to improve sensitivity and specificity.

Indexed as

AthletesAthlete’s heartcoronary artery originechocardiography

Identifiers

PMID33672577
PMCPMC7924023
OpenAlexW3131155028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.