Evidence map›Paper›PMID 33672553›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Health Potential of

Ida Ceravolo, Federica Mannino, Natasha Irrera, Francesco Squadrito, Domenica Altavilla, Giorgia Ceravolo, Giovanni Pallio, Letteria Minutoli

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Lycopene andPharmaceuticals (Basel, Switzerland) · 2024
    Article
  8. Article
  9. Review
  10. Medicinal Plants Used for Eye Conditions in Mexico-A Review.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Multiple Beneficial Effects of Aloesone fromMolecules (Basel, Switzerland) · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ida CeravoloDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Federica ManninoDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Natasha IrreraDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Francesco SquadritoDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0000-0002-8868-0762
Domenica AltavillaDepartment of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Giorgia CeravoloDepartment of Human Pathology and Evolutive Age "Gaetano Barresi", University of Messina, Via C. Valeria, 98125 Messina, Italy.
Giovanni PallioDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0000-0002-4187-2265
Letteria MinutoliDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fuchs endothelial corneal dystrophy (FECD) is characterized by the gradual deterioration of corneal endothelial cells (CECs) and is the most common cause of corneal transplantation worldwide. CECs apoptosis caused by oxidative stress plays a pivotal role in the pathogenesis of FECD. Antioxidant compounds have been of considerable significance as a candidate treatment in the management of corneal diseases. Based on these findings, the objective of this study was to evaluate the effects of an aloe extract with antioxidant properties, in an "in vitro" model of FECD. Human corneal epithelial (HCE) cells were preincubated with aloe extract 100 μg/mL, two hours before hydrogen peroxide (H

Indexed as

Aloe veraantioxidantapoptosiscorneal epithelial cellsinflammationoxidative stressROS

Identifiers

PMID33672553
PMCPMC7923787
OpenAlexW3129646006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.