ReviewBrain sciences2021
Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature.
Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Cognitive Decline and Illness Progression in Bipolar Disorder.Advances in therapy · 2026Pooled it
- Circulating Cell-Free DNA in Psychiatric Disorders: Current Evidence, Inflammation-Based Stratification, and Future Perspectives.International journal of molecular sciences · 2026Review
- Differential impact of manic versus depressive episode recurrence on longitudinal gray matter volume changes in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Clinical staging and profiling of affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Increased granulovacuolar degeneration in the thalamus and higher neurofibrillary tangle Braak stages in bipolar disorder.Psychiatry and clinical neurosciences · 2025Article
- Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Are Elevated in Bipolar Depression: Evidence for Neuroprogression and Astrogliosis.Bipolar disorders · 2025Article
- Transdiagnostic Clinical Staging in Youth Mental Health: A primer for clinical practice.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Review
- Brain 18FDG-PET pattern in cognitively impaired elderly patients with bipolar disorder.International journal of bipolar disorders · 2024Article
- Perceived cognitive loss, symptomology, and psychological well-being with bipolar disorder.International journal of bipolar disorders · 2024Article
- Psychiatric Disease as a Potential Risk Factor for Dementia: A Narrative Review.Brain sciences · 2024Review
- Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan.BJPsych open · 2023Article
- Preventive effect of aripiprazole once monthly on rehospitalization for bipolar disorder: A multicenter 1-year retrospective mirror image study.Neuropsychopharmacology reports · 2023Article
- Utilizing the Systemic Immune-Inflammation Index and Blood-Based Biomarkers in Association with Treatment Responsiveness amongst Patients with Treatment-Resistant Bipolar Depression.Journal of personalized medicine · 2023Article
- Brain age and cognitive functioning in first-episode bipolar disorder.Psychological medicine · 2023Article
- Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence.Molecular psychiatry · 2023Review
- Prioritizing Treatment Goals of People Diagnosed with Bipolar I Disorder in the US: Best-Worst Scaling Results.Patient preference and adherence · 2023Article
- Long-term effect of childhood trauma: Role of inflammation and white matter in mood disorders.Brain, behavior, & immunity - health · 2022Article
- The longitudinal trajectory of emotion regulation and associated neural activity in patients with bipolar disorder: A prospective fMRI study.Acta psychiatrica Scandinavica · 2022Article
- Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?Antioxidants (Basel, Switzerland) · 2022Review
- Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder.Bipolar disorders · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.