Evidence map›Paper›PMID 33672387›Full record

ArticleInternational journal of molecular sciences2021

Mutation of GGMP Repeat Segments of

Stanley Makumire, Tendamudzimu Harmfree Dongola, Graham Chakafana, Lufuno Tshikonwane, Cecilia Tshikani Chauke, Tarushai Maharaj, Tawanda Zininga, Addmore Shonhai

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Frontiers in cell and developmental biology · 2022
    Review
  7. Inhibition ofFrontiers in molecular biosciences · 2022
    Article
  8. Article
  9. Characterization of an AtypicalInternational journal of molecular sciences · 2021
    Article
  10. Biophysical reviews · 2021
    Article
  11. Heat Shock Proteins of Malaria: Highlights and Future Prospects.Advances in experimental medicine and biology · 2021
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Stanley MakumireDepartment of Biochemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa.ORCID 0000-0003-4355-1382
Tendamudzimu Harmfree DongolaDepartment of Biochemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa.
Graham ChakafanaDepartment of Biochemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa.
Lufuno TshikonwaneDepartment of Biochemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa.
Cecilia Tshikani ChaukeDepartment of Biochemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa.ORCID 0000-0003-1174-5852
Tarushai MaharajDepartment of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa.ORCID 0000-0002-2934-7310
Tawanda ZiningaDepartment of Biochemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa.ORCID 0000-0001-8689-0152
Addmore ShonhaiDepartment of Biochemistry, University of Venda, Private Bag X5050, Thohoyandou 0950, South Africa.ORCID 0000-0003-3203-0602
University of Venda · ZAStellenbosch University · ZAUniversity of Cape Town · ZA

Funding

African-German Network of Excellence N/ADeutsche Gesellschaft für Erziehungswissenschaft L1/402/14-1National Research Foundation of South Africa 75464National Research Foundation of South Africa 92598
6 · The paper itself

Abstract

Parasitic organisms especially those of the Apicomplexan phylum, harbour a cytosol localised canonical Hsp70 chaperone. One of the defining features of this protein is the presence of GGMP repeat residues sandwiched between α-helical lid and C-terminal EEVD motif. The role of the GGMP repeats of Hsp70s remains unknown. In the current study, we introduced GGMP mutations in the cytosol localised Hsp70-1 of

Indexed as

MutationPlasmodium falciparumCircular DichroismEscherichia coli ProteinsGenetic Complementation TestHeat-Shock ProteinsHSP70 Heat-Shock ProteinsHSP72 Heat-Shock ProteinsModels, MolecularMolecular ChaperonesProtein StabilityProtozoan ProteinsRecombinant ProteinsRepetitive Sequences, Amino AcidSpectrometry, FluorescencednaK protein, E coliEscherichia coli ProteinsHeat-Shock ProteinsHSP70 Heat-Shock ProteinsHSP72 Heat-Shock ProteinsMolecular ChaperonesPfHop protein, Plasmodium falciparumProtozoan ProteinsRecombinant ProteinschaperoneGGMP repeatsHopHsp70malariaPlasmodium falciparum

Identifiers

PMID33672387
PMCPMC7926355
OpenAlexW3132338743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.