Evidence map›Paper›PMID 33672377›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd

Martin Vojtek, Salomé Gonçalves-Monteiro, Edgar Pinto, Sára Kalivodová, Agostinho Almeida, Maria P M Marques, Ana L M Batista de Carvalho, Clara B Martins, Helder Mota-Filipe, Isabel M P L V O Ferreira and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. PdJournal of medicinal chemistry · 2024
    Article
  6. Article
  7. Article
  8. Effect of PdInternational journal of molecular sciences · 2022
    Article
  9. Article
  10. PdBiomedicines · 2022
    Article
  11. Article
  12. Impact of the PdInternational journal of molecular sciences · 2021
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Martin VojtekLAQV/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-9257-7020
Salomé Gonçalves-MonteiroLAQV/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Edgar PintoLAQV/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Sára KalivodováLAQV/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Agostinho AlmeidaLAQV/REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-1297-3198
Maria P M Marques"Molecular Physical-Chemistry" R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0002-8391-0055
Ana L M Batista de Carvalho"Molecular Physical-Chemistry" R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.ORCID 0000-0003-1280-3321
Clara B Martins"Molecular Physical-Chemistry" R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Helder Mota-FilipeiMed.ULisboa, Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.ORCID 0000-0003-3045-2553
Isabel M P L V O FerreiraLAQV/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Carmen DinizLAQV/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0003-4668-9360
Universidade do Porto · PTUniversity of Coimbra · PTUniversity of Lisbon · PT

Funding

Fundação para a Ciência e a Tecnologia PD/BD/135460/2017Fundação para a Ciência e a Tecnologia PTDC/QEQ-MED/1890/2014Fundação para a Ciência e a Tecnologia UIDB/00070/2020Fundação para a Ciência e a Tecnologia UID/QUI/50006/2020
6 · The paper itself

Abstract

Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd

Indexed as

cancercisplatinICP-MSin vivometal complexesPd(II)-based drugspolyaminestissue

Identifiers

PMID33672377
PMCPMC7926495
OpenAlexW3130084178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.