Runx3 Induces a Cell Shape Change and Suppresses Migration and Metastasis of Melanoma Cells by Altering a Transcriptional Profile.

Ning Wang, Haiying Zhang, Xiulin Cui, Chao Ma, Linghui Wang, Wenguang Liu

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.2field-weighted citation impact, top 48% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

Epigenetics of Malignant Melanoma: Mechanisms, Diagnostic Approaches and Therapeutic Applications.Oncology research · 2026
Review
Single-Cell RNA Sequencing Reveals Potential Mechanism of RUNX3 Reshaping Tumor Microenvironment in Non-small-cell Lung Cancer.Annals of surgical oncology · 2025
Article
RUNX transcription factors: biological functions and implications in cancer.Clinical and experimental medicine · 2024
Review
Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy.Frontiers in immunology · 2024
Review
The role and mechanism of compressive stress in tumor.Frontiers in oncology · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ning WangInstitute of Genetics and Cell Biology, School of Life Sciences, Northeast Normal University, No. 5268, Renmin St., Changchun 130024, China.

Haiying ZhangKey Laboratory of Pathobiology of Ministry of Education, Norman Bethune College of Medicine, Jilin University, No. 126, Xinmin St., Changchun 130021, China.

Xiulin CuiInstitute of Genetics and Cell Biology, School of Life Sciences, Northeast Normal University, No. 5268, Renmin St., Changchun 130024, China.

Chao MaInstitute of Genetics and Cell Biology, School of Life Sciences, Northeast Normal University, No. 5268, Renmin St., Changchun 130024, China.

Linghui WangInstitute of Genetics and Cell Biology, School of Life Sciences, Northeast Normal University, No. 5268, Renmin St., Changchun 130024, China.

Wenguang LiuInstitute of Genetics and Cell Biology, School of Life Sciences, Northeast Normal University, No. 5268, Renmin St., Changchun 130024, China.

Northeast Normal University · CNJilin University · CN

Funding

Natural Science Foundation of Jilin Province 20180101257JC

6 · The paper itself

Abstract

Runt-related transcription factor-3 (Runx3) is a tumor suppressor, and its contribution to melanoma progression remains unclear. We previously demonstrated that Runx3 re-expression in B16-F10 melanoma cells changed their shape and attenuated their migration. In this study, we found that Runx3 re-expression in B16-F10 cells also suppressed their pulmonary metastasis. We performed microarray analysis and uncovered an altered transcriptional profile underlying the cell shape change and the suppression of migration and metastasis. This altered transcriptional profile was rich in Gene Ontology/Kyoto Encyclopedia of Genes and Genomes (GO/KEGG) annotations relevant to adhesion and the actin cytoskeleton and included differentially expressed genes for some major extracellular matrix (ECM) proteins as well as genes that were inversely associated with the increase in the metastatic potential of B16-F10 cells compared to B16-F0 melanoma cells. Further, we found that this altered transcriptional profile could have prognostic value, as evidenced by myelin and lymphocyte protein (

Indexed as

AnimalsCell MovementCell ShapeCore Binding Factor Alpha 3 SubunitEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLung NeoplasmsMelanoma, ExperimentalMiceMice, Inbred C57BLMyelin and Lymphocyte-Associated Proteolipid ProteinsNeoplasmsPrognosisCore Binding Factor Alpha 3 SubunitMAL protein, humanMal protein, mouseMyelin and Lymphocyte-Associated Proteolipid ProteinsRunx3 protein, humanRunx3 protein, mouseactin cytoskeletonadhesionextracellular matrixMalmelanomametastasisRunx3transcriptional profile

Identifiers

PMID33672337

DOI10.3390/ijms22042219

PMCPMC7926509

OpenAlexW3131887257

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.