Evidence map›Paper›PMID 33672285›Full record

ReviewDiagnostics (Basel, Switzerland)2021

A Systematic Review of PET Textural Analysis and Radiomics in Cancer.

Manuel Piñeiro-Fiel, Alexis Moscoso, Virginia Pubul, Álvaro Ruibal, Jesús Silva-Rodríguez, Pablo Aguiar

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Article
  5. Article
  6. Article
  7. Texture analysis and metabolic parameters ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Clinical scoring systems, molecular subtypes and baseline [Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. 2-[Medicina (Kaunas, Lithuania) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manuel Piñeiro-FielMolecular Imaging and Medical Physics Group, Radiology Department, Faculty of Medicine, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain.ORCID 0000-0003-4515-7784
Alexis MoscosoMolecular Imaging and Medical Physics Group, Radiology Department, Faculty of Medicine, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Virginia PubulMolecular Imaging Research Group, Nuclear Medicine Department, University Hospital and Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.
Álvaro RuibalMolecular Imaging and Medical Physics Group, Radiology Department, Faculty of Medicine, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Jesús Silva-RodríguezMolecular Imaging Research Group, Nuclear Medicine Department, University Hospital and Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.
Pablo AguiarMolecular Imaging and Medical Physics Group, Radiology Department, Faculty of Medicine, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain.ORCID 0000-0002-7322-2195

Funding

Instituto de Salud Carlos III dts17/00138
6 · The paper itself

Abstract

backgroundAlthough many works have supported the utility of PET radiomics, several authors have raised concerns over the robustness and replicability of the results. This study aimed to perform a systematic review on the topic of PET radiomics and the used methodologies.

methodsPubMed was searched up to 15 October 2020. Original research articles based on human data specifying at least one tumor type and PET image were included, excluding those that apply only first-order statistics and those including fewer than 20 patients. Each publication, cancer type, objective and several methodological parameters (number of patients and features, validation approach, among other things) were extracted.

resultsA total of 290 studies were included. Lung (28%) and head and neck (24%) were the most studied cancers. The most common objective was prognosis/treatment response (46%), followed by diagnosis/staging (21%), tumor characterization (18%) and technical evaluations (15%). The average number of patients included was 114 (median = 71; range 20-1419), and the average number of high-order features calculated per study was 31 (median = 26, range 1-286).

conclusionsPET radiomics is a promising field, but the number of patients in most publications is insufficient, and very few papers perform in-depth validations. The role of standardization initiatives will be crucial in the upcoming years.

Indexed as

cancerheterogeneityPETradiomicstextural analysis

Identifiers

PMID33672285
PMCPMC7926413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.