Evidence map›Paper›PMID 33672226›Full record

ArticleViruses2021

Dengue Virus Serotype 2 Intrahost Diversity in Patients with Different Clinical Outcomes.

Maria Celeste Torres, Marcos Cesar Lima de Mendonça, Cintia Damasceno Dos Santos Rodrigues, Vagner Fonseca, Mario Sergio Ribeiro, Ana Paula Brandão, Rivaldo Venâncio da Cunha, Ana Isabel Dias, Lucy Santos Vilas Boas, Alvina Clara Felix and 5 more

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  11. Review
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  14. Microbiology spectrum · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maria Celeste TorresLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, 21040-360 Rio de Janeiro, Brazil.ORCID 0000-0001-8955-8972
Marcos Cesar Lima de MendonçaLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, 21040-360 Rio de Janeiro, Brazil.
Cintia Damasceno Dos Santos RodriguesLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, 21040-360 Rio de Janeiro, Brazil.
Vagner FonsecaKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, 4041 Durban, South Africa.ORCID 0000-0001-5521-6448
Mario Sergio RibeiroSuperintendência Secretaria de Vigilância em Saúde do Estado do Rio de Janeiro, 20031-142 Rio de Janeiro, Brazil.
Ana Paula BrandãoLaboratório Central Noel Nutels/LACEN, 20231-092 Rio de Janeiro, Brazil.
Rivaldo Venâncio da CunhaCoordenação de Vigilância em Saúde e Laboratórios de Referência da Fundação Oswaldo Cruz, FIOCRUZ, 21040-360 Rio de Janeiro, Brazil.ORCID 0000-0002-6622-7043
Ana Isabel DiasInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, Brazil.
Lucy Santos Vilas BoasInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, Brazil.
Alvina Clara FelixInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, 05403-000 São Paulo, Brazil.
Maira Alves PereiraFundação Ezequiel Dias/LACEN, 31630-903 Belo Horizonte, Brazil.
Luzia Maria de Oliveira PintoLaboratório de Imunologia Viral, Instituto Oswaldo Cruz, Fiocruz, 21040-360 Rio de Janeiro, Brazil.ORCID 0000-0001-7127-0276
Anavaj SakuntabhaiFunctional Genetics of Infectious Diseases, Department of Global Health, Institut Pasteur, 75015 Paris, France.
Ana Maria Bispo de FilippisLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, 21040-360 Rio de Janeiro, Brazil.
On Behalf Of ZikAction ConsortiumLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, 21040-360 Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrahost genetic diversity is thought to facilitate arbovirus adaptation to changing environments and hosts, and it might also be linked to viral pathogenesis. Dengue virus serotype 2 (DENV-2) has circulated in Brazil since 1990 and is associated with severe disease and explosive outbreaks. Intending to shed light on the viral determinants for severe dengue pathogenesis, we sought to analyze the DENV-2 intrahost genetic diversity in 68 patient cases clinically classified as dengue fever (

Indexed as

AdolescentAdultAgedAged, 80 and overBrazilChildChild, PreschoolDengueDengue VirusFemaleGenetic VariationGenome, ViralHumansInfantMaleMiddle Agednonstructural protein 2B, Dengue virusViral Nonstructural Proteinsdengue virusintrahost diversityserotype 2severe disease

Identifiers

PMID33672226
PMCPMC7926750

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.