Evidence map›Paper›PMID 33672054›Full record

ArticleViruses2021

Structure-Based Identification of Natural Products as SARS-CoV-2 M

Shiv Bharadwaj, Sherif Aly El-Kafrawy, Thamir A Alandijany, Leena Hussein Bajrai, Altaf Ahmad Shah, Amit Dubey, Amaresh Kumar Sahoo, Umesh Yadava, Mohammad Amjad Kamal, Esam Ibraheem Azhar and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  4. Review
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  9. Review
  10. Discovery of Small Molecules fromLife (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Inhibition of the main protease of SARS-CoV-2 (MComputational and structural biotechnology journal · 2022
    Review
  13. Article
  14. COVID-19 in 2021.Viruses · 2021
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Shiv BharadwajDepartment of Biotechnology, Institute of Biotechnology, College of Life and Applied Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Korea.ORCID 0000-0003-2832-8617
Sherif Aly El-KafrawySpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.ORCID 0000-0002-3667-7529
Thamir A AlandijanySpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.ORCID 0000-0001-9130-4031
Leena Hussein BajraiSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.ORCID 0000-0001-6889-0730
Altaf Ahmad ShahDepartment of Biosciences, Integral University, Lucknow 226026, India.
Amit DubeyComputational Chemistry and Drug Discovery Division, Quanta Calculus Pvt. Ltd., Kushinagar 274203, India.
Amaresh Kumar SahooDepartment of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad 211015, Uttar Pradesh, India.
Umesh YadavaDepartment of Physics, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur 273009, India.ORCID 0000-0002-9127-532X
Mohammad Amjad KamalSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.ORCID 0000-0003-0088-0565
Esam Ibraheem AzharSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.ORCID 0000-0002-1736-181X
Sang Gu KangDepartment of Biotechnology, Institute of Biotechnology, College of Life and Applied Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Korea.ORCID 0000-0002-5216-5494
Vivek Dhar DwivediCentre for Bioinformatics, Computational and Systems Biology, Pathfinder Research and Training Foundation, Greater Noida 201308, India.ORCID 0000-0003-0767-1328
King Abdulaziz University · SAYeungnam University · KRDeen Dayal Upadhyaya Gorakhpur University · INIndian Institute of Information Technology Allahabad · INIntegral University · IN

Funding

This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah under Grant Number GCV19-47-1441. The authors therefore acknowledge with thanks DSR for financial and technical support. GCV19-47-1441
6 · The paper itself

Abstract

Coronavirus disease-19 (COVID-19) pandemic, caused by the novel SARS-CoV-2 virus, continues to be a global threat. The number of cases and deaths will remain escalating due to the lack of effective therapeutic agents. Several studies have established the importance of the viral main protease (M

Indexed as

Antiviral AgentsBinding SitesCoronavirus 3C ProteasesDrug DiscoveryEchinaceaFlavonesFructansGlycosidesInulinMolecular Docking SimulationPhytochemicalsProtease InhibitorsProtein BindingQuinic Acid1,3-dicaffeoylquinic acid3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesechinacosideFlavonesFructansGlycosidesInulinlevanPhytochemicalsProtease InhibitorsquercetagetinQuinic AcidCOVID-19Echinacea-angustifoliamolecular dynamics simulationnatural productsQuercetagetin 7-glucosideSARS-CoV-2

Identifiers

PMID33672054
PMCPMC7919488
OpenAlexW3131420733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.