Evidence map›Paper›PMID 33671934›Full record

ArticleMicroorganisms2021

HBcAb Positivity Is a Risk Factor for an Increased Detectability of HIV RNA after Switching to a Two-Drug Regimen Lamivudine-Based (2DR-3TC-Based) Treatment: Analysis of a Multicenter Italian Cohort.

Vincenzo Malagnino, Elisabetta Teti, Mirko Compagno, Luigi Coppola, Romina Salpini, Valentina Svicher, Monica Basso, Giuliana Battagin, Sandro Panese, Maria Cristina Rossi and 6 more

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Vincenzo MalagninoClinica di Malattie Infettive, Policlinico Tor Vergata di Roma, 00133 Rome, Italy.ORCID 0000-0002-6561-5298
Elisabetta TetiClinica di Malattie Infettive, Policlinico Tor Vergata di Roma, 00133 Rome, Italy.
Mirko CompagnoClinica di Malattie Infettive, Policlinico Tor Vergata di Roma, 00133 Rome, Italy.ORCID 0000-0002-6372-5434
Luigi CoppolaClinica di Malattie Infettive, Policlinico Tor Vergata di Roma, 00133 Rome, Italy.
Romina SalpiniDipartimento di Medicina Sperimentale, Università degli Studi di Roma Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-2488-2082
Valentina SvicherDipartimento di Medicina Sperimentale, Università degli Studi di Roma Tor Vergata, 00133 Rome, Italy.
Monica BassoDipartimento di Medicina Molecolare, Università degli Studi di Padova, 35128 Padova, Italy.
Giuliana BattaginUOC Malattie Infettive, Ospedale di Vicenza, 36100 Vicenza, Italy.
Sandro PaneseUOC Malattie Infettive Ospedale di Venezia, 30122 Venezia, Italy.
Maria Cristina RossiUOC Malattie Infettive Ospedale di Treviso, 31100 Treviso, Italy.
Renzo ScaggianteUOC Malattei Infettive, Ospedale di Belluno, 32100 Belluno, Italy.
Daniela ZagoDipartimento di Medicina Molecolare, Università degli Studi di Padova, 35128 Padova, Italy.
Marco IannettaClinica di Malattie Infettive, Policlinico Tor Vergata di Roma, 00133 Rome, Italy.ORCID 0000-0002-6938-8627
Saverio Giuseppe ParisiDipartimento di Medicina Molecolare, Università degli Studi di Padova, 35128 Padova, Italy.
Massimo AndreoniClinica di Malattie Infettive, Policlinico Tor Vergata di Roma, 00133 Rome, Italy.
Loredana SarmatiClinica di Malattie Infettive, Policlinico Tor Vergata di Roma, 00133 Rome, Italy.
University of Rome Tor Vergata · ITPoliclinico Tor Vergata · ITUniversity of Padua · ITAULSS 2 Marca Trevigiana · ITOspedale Civile di Venezia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate whether the presence of anti-hepatitis B (HBV) c antibodies (HBcAb positivity) could influence the control of Human Immunodeficiency Virus (HIV) viremia in patients living with HIV (PLWH) who switch a to two-drug antiretroviral therapy (2DR) containing lamivudine (3TC) (2DR-3TC). A retrospective observational multicenter study was conducted on 166 PLWH switching to the 2DR-3TC-based regimen: 58 HBcAb-positive and 108 HBcAb-negative patients. The HBcAb-positive PLWH group demonstrated a significantly higher percentage of subjects with very low-level viremia at all time points after switching (6th month: <31% vs. 17.6%,

Indexed as

2DR3TC/DTGanti-HBcdual therapyHIV/HBV coinfection

Identifiers

PMID33671934
PMCPMC7919011
OpenAlexW3130408101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.