Evidence map›Paper›PMID 33671648›Full record

ReviewPolymers2021

Injectable Hydrogels: From Laboratory to Industrialization.

Jose Maria Alonso, Jon Andrade Del Olmo, Raul Perez Gonzalez, Virginia Saez-Martinez

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jose Maria AlonsoI+Med. S. Coop., Parque Tecnológico de Alava. Albert Einstein 15, Nave 15, 01510 Vitoria-Gasteiz, Spain.
Jon Andrade Del OlmoI+Med. S. Coop., Parque Tecnológico de Alava. Albert Einstein 15, Nave 15, 01510 Vitoria-Gasteiz, Spain.
Raul Perez GonzalezI+Med. S. Coop., Parque Tecnológico de Alava. Albert Einstein 15, Nave 15, 01510 Vitoria-Gasteiz, Spain.
Virginia Saez-MartinezI+Med. S. Coop., Parque Tecnológico de Alava. Albert Einstein 15, Nave 15, 01510 Vitoria-Gasteiz, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transfer of some innovative technologies from the laboratory to industrial scale is many times not taken into account in the design and development of some functional materials such as hydrogels to be applied in the biomedical field. There is a lack of knowledge in the scientific field where many aspects of scaling to an industrial process are ignored, and products cannot reach the market. Injectable hydrogels are a good example that we have used in our research to show the different steps needed to follow to get a product in the market based on them. From synthesis and process validation to characterization techniques used and assays performed to ensure the safety and efficacy of the product, following regulation, several well-defined protocols must be adopted. Therefore, this paper summarized all these aspects due to the lack of knowledge that exists about the industrialization of injectable products with the great importance that it entails, and it is intended to serve as a guide on this area to non-initiated scientists. More concretely, in this work, the characteristics and requirements for the development of injectable hydrogels from the laboratory to industrial scale is presented in terms of (i) synthesis techniques employed to obtain injectable hydrogels with tunable desired properties, (ii) the most common characterization techniques to characterize hydrogels, and (iii) the necessary safety and efficacy assays and protocols to industrialize and commercialize injectable hydrogels from the regulatory point of view. Finally, this review also mentioned and explained a real example of the development of a natural hyaluronic acid hydrogel that reached the market as an injectable product.

Indexed as

hydrogelsindustrializationinjectablepolysaccharidesregulationscale-up

Identifiers

PMID33671648
PMCPMC7926321

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.