ArticleNutrients2021
Mediterranean Diet and Risk of Dementia and Alzheimer's Disease in the EPIC-Spain Dementia Cohort Study.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Cost-effectiveness analysis of the treatment pathway after trastuzumab treatment failure in patients with HER2-positive advanced breast cancer: a chinese health system perspective.BMC health services research · 2026Pooled it
- Dietary Intake, Mediterranean and Nordic Diet Adherence in Alzheimer's Disease and Dementia: A Systematic Review.Nutrients · 2025Pooled it
- Mediterranean diet and dementia: MRI marker evidence from meta-analysis.European journal of medical research · 2025Pooled it
- Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Whole Dietary Patterns, Cognitive Decline and Cognitive Disorders: A Systematic Review of Prospective and Intervention Studies.Nutrients · 2023Pooled it
- Effect of nutrition in Alzheimer's disease: A systematic review.Frontiers in neuroscience · 2023Pooled it
- The effects of olive oil consumption on cognitive performance: a systematic review.Frontiers in nutrition · 2023Pooled it
- Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk.Nutrients · 2024Trial
- Gut Microbiome Changes in Preclinical Alzheimer's Disease.Nutrients · 2026Review
- An Anti-Inflammatory Signature Across Pain and Cognition: Not All Mediterranean Diets Are Equal.Nutrients · 2026Article
- Mental health and gut-brain crosstalk: implications for depression and Alzheimer's disease.Neuroscience applied · 2026Review
- Nonlinear L-shaped association between composite dietary antioxidant index and risk of dementia: a prospective cohort study.Frontiers in public health · 2026Article
- Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein.Nutrients · 2025Review
- Impact of Diverse Dietary Patterns on Cognitive Health: Cumulative Evidence from Prospective Cohort Studies.Nutrients · 2025Review
- Mediterranean dietary pattern and risk of neurodegenerative diseases in a cohort of Swedish women.NPJ Parkinson's disease · 2025Article
- Impact of Diets on Cognitive and Clinical Outcomes in Alzheimer's Disease: A Scoping Review.Cureus · 2025Review
- Factors Affecting Resilience and Prevention of Alzheimer's Disease and Related Dementias.Annals of neurology · 2024Review
- Sex-specific chrono-nutritional patterns and association with body weight in a general population in Spain (GCAT study).The international journal of behavioral nutrition and physical activity · 2024Article
- The Role of Diet and Gut Microbiota in Alzheimer's Disease.Nutrients · 2024Review
- The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer's and Parkinson's Diseases.Nutrients · 2024Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Mediterranean diet (MD) has shown to reduce the occurrence of several chronic diseases. To evaluate its potential protective role on dementia incidence we studied 16,160 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain Dementia Cohort study recruited between 1992-1996 and followed up for a mean (±SD) of 21.6 (±3.4) years. A total of 459 incident cases of dementia were ascertained through expert revision of medical records. Data on habitual diet was collected through a validated diet history method to assess adherence to the relative Mediterranean Diet (rMED) score. Hazard ratios (HR) of dementia by rMED levels (low, medium and high adherence levels: ≤6, 7-10 and ≥11 points, respectively) were estimated using multivariable Cox models, whereas time-dependent effects were evaluated using flexible parametric Royston-Parmar (RP) models. Results of the fully adjusted model showed that high versus low adherence to the categorical rMED score was associated with a 20% (HR = 0.80, 95%CI: 0.60-1.06) lower risk of dementia overall and HR of dementia was 8% (HR = 0.92, 0.85-0.99,
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