ArticleMaterials (Basel, Switzerland)2021
1,2-Diarylethanols-A New Class of Compounds That Are Toxic to
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Enzymatic Synthesis of a Novel Coumarin Aminophosphonates: Antibacterial Effects and Oxidative Stress Modulation on SelectedInternational journal of molecular sciences · 2023Article
- Synthesis and Antimicrobial Activity of the PathogenicInternational journal of molecular sciences · 2023Article
- Aluminium(III) Oxide-The Silent Killer of Bacteria.Molecules (Basel, Switzerland) · 2023Article
- A Novel Biocidal Nanocomposite: Spherical Silica with Silver Ions Anchored at the Surface.International journal of molecular sciences · 2022Article
- The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents.Molecules (Basel, Switzerland) · 2022Article
- Promiscuous Lipase-Catalyzed Knoevenagel-Phospha-Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates.International journal of molecular sciences · 2022Article
- Functionalised Anodised Aluminium Oxide as a Biocidal Agent.International journal of molecular sciences · 2022Article
- Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity inMolecules (Basel, Switzerland) · 2022Article
- Relationship between Structure and Antibacterial Activity of α-Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik-Fields Reaction.Materials (Basel, Switzerland) · 2022Article
- Promiscuous Lipase-Catalyzed Markovnikov Addition of H-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives.Materials (Basel, Switzerland) · 2022Article
- Article
- The Synthesis and Evaluation of Amidoximes as Cytotoxic Agents on Model BacterialMaterials (Basel, Switzerland) · 2021Article
- The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model BacterialMaterials (Basel, Switzerland) · 2021Article
- Pyridine Derivatives-A New Class of Compounds That Are Toxic toMaterials (Basel, Switzerland) · 2021Article
- δ-Lactones-A New Class of Compounds That Are Toxic toMaterials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An initial study of 1,2-diarylethanols derivatives as new potential antibacterial drugs candidates was conducted. Particular emphasis was placed on the selection of the structure of 1,2-diarylethanols with the highest biological activity of lipopolysaccharides (LPS) in the model strains of Escherichia coli K12 (without LPS in its structure) and R2-R4 (with different lengths of LPS in its structure). In the presented studies, based on the conducted minimum inhibitory concentration (MIC) and MBC tests, it was demonstrated that the antibacterial (toxic) effect of 1,2-diarylethanols depends on their structure and the length of LPS bacteria in the membrane of specific strains. Moreover, the oxidative damage of bacterial DNA isolated from bacteria after modification with newly synthesized compounds after application of the repair enzyme Fpg glycosylases was analysed. The analysed damage values were compared with modification with appropriate antibiotics; bacterial DNA after the use of kanamycin, streptomycin, ciprofloxacin, bleomycin and cloxicillin. The presented research clearly shows that 1,2-diarylethanol derivatives can be used as potential candidates for substitutes for new drugs, e.g., the analysed antibiotics. Their chemical and biological activity is related to two aromatic groups and the corresponding chemical groups in the structure of the substituent. The observed results are particularly important in the case of increasing bacterial resistance to various drugs and antibiotics, especially in nosocomial infections and neoplasms, and in the era of pandemics caused by microorganisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.