Evidence map›Paper›PMID 33671478›Full record

ArticleCancers2021

The Claudin-Low Subtype of High-Grade Serous Ovarian Carcinoma Exhibits Stem Cell Features.

Chiara Romani, Davide Capoferri, Elisabetta Grillo, Marco Silvestri, Michela Corsini, Laura Zanotti, Paola Todeschini, Antonella Ravaggi, Eliana Bignotti, Franco Odicino and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Claudins as biomarkers of differential diagnosis and prognosis of tumors.Journal of cancer research and clinical oncology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Chiara RomaniAngelo Nocivelli Institute of Molecular Medicine, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.ORCID 0000-0001-7916-2704
Davide CapoferriAngelo Nocivelli Institute of Molecular Medicine, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.ORCID 0000-0002-1251-8136
Elisabetta GrilloDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-8403-0607
Marco SilvestriDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-8283-9130
Michela CorsiniDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-8673-4376
Laura ZanottiAngelo Nocivelli Institute of Molecular Medicine, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Paola TodeschiniAngelo Nocivelli Institute of Molecular Medicine, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Antonella RavaggiAngelo Nocivelli Institute of Molecular Medicine, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.ORCID 0000-0003-4661-9979
Eliana BignottiAngelo Nocivelli Institute of Molecular Medicine, University of Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Franco OdicinoDivision of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.ORCID 0000-0001-8870-4739
Enrico SartoriDivision of Obstetrics and Gynecology, ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Stefano CalzaDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0003-4996-7995
Stefania MitolaDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-5557-738X
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Brescia · ITFondazione IRCCS Istituto Nazionale dei Tumori · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG17276Fondazione Umberto Veronesi fellowItalian Ministry of University 20178S4EK9
6 · The paper itself

Abstract

Claudin-low cancer (CL) represents a rare and biologically aggressive variant of epithelial tumor. Here, we identified a claudin-low molecular profile of ovarian high-grade serous carcinoma (HGSOC), which exhibits the main characteristics of the homonym breast cancer subtype, including low epithelial differentiation and high mesenchymal signature. Hierarchical clustering and a centroid based algorithm applied to cell line collection expression dataset labeled 6 HGSOC cell lines as CL. These have a high energy metabolism and are enriched in CD44

Indexed as

cancer stem cellsclaudin-lowEMTmolecular profilingserous ovarian cancer

Identifiers

PMID33671478
PMCPMC7926503
OpenAlexW3131664690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.