Evidence map›Paper›PMID 33671472›Full record

ArticleInternational journal of molecular sciences2021

Activation of Apoptosis in a βB1-CTGF Transgenic Mouse Model.

Maximilian Weiss, Sabrina Reinehr, Ana M Mueller-Buehl, Johanna D Doerner, Rudolf Fuchshofer, Gesa Stute, H Burkhard Dick, Stephanie C Joachim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  7. Towards an Understanding of Retinal Diseases and Novel Treatment.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maximilian WeissExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Sabrina ReinehrExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.ORCID 0000-0002-4770-0210
Ana M Mueller-BuehlExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Johanna D DoernerExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Rudolf FuchshoferInstitute of Human Anatomy and Embryology, University Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany.
Gesa StuteExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
H Burkhard DickExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Stephanie C JoachimExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.ORCID 0000-0001-7056-0829
University Hospitals of the Ruhr-University of Bochum · DEUniversity of Regensburg · DE

Funding

Ernst und Berta Grimmke Stiftung noneFoRUM (Ruhr-University Bochum) F903N-2017Verein Glück im Blick none
6 · The paper itself

Abstract

To reveal the pathomechanisms of glaucoma, a common cause of blindness, suitable animal models are needed. As previously shown, retinal ganglion cell and optic nerve degeneration occur in βB1-CTGF mice. Here, we aimed to determine possible apoptotic mechanisms and degeneration of different retinal cells. Hence, retinae were processed for immunohistology (

Indexed as

ApoptosisAnimalsCell CountConnective Tissue Growth FactorMice, TransgenicModels, AnimalNeurofilament ProteinsPhotoreceptor Cells, VertebrateRetinal Bipolar CellsRetinal Ganglion CellsSynapsesConnective Tissue Growth Factorneurofilament protein HNeurofilament ProteinsapoptosisBax/Bcl2caspase 3neurofilament Hprimary open-angle glaucomasynapseβB1-CTGF

Identifiers

PMID33671472
PMCPMC7922353
OpenAlexW3131366758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.