SynthesisInternational journal of molecular sciences2021
An Evidence-Based Systematic Review of Human Knee Post-Traumatic Osteoarthritis (PTOA): Timeline of Clinical Presentation and Disease Markers, Comparison of Knee Joint PTOA Models and Early Disease Implications.
Synthesis in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Investigating the therapeutic impact of platelet-rich plasma on knee, hip, and traumatic osteoarthritis: a meta-analysis and systematic review.BMC musculoskeletal disorders · 2026Pooled it
- Pooled it
- Human synovial fluid interleukin-6, but not type II collagen breakdown, positively correlated with pain after anterior cruciate ligament injury and reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Trial
- A single step, centrifuge-free method to harvest bone marrow highly concentrated in mesenchymal stem cells: results of a pilot trial.International orthopaedics · 2022Trial
- Trial
- Limited Added Effect of Proline-Rich P6 Peptide to Cross-Linked Hyaluronic Acid After Partial Lateral Meniscectomy in Sheep.Smart medicine · 2026Article
- The Effect of Physical, Biochemical, and Electrical Culture Conditions on Articular Chondrocytes Used for Cartilage Tissue Engineering: A Narrative Review.International journal of molecular sciences · 2026Review
- An immunoregenerative approach to mitigate post-traumatic osteoarthritis after intra-articular fracture.Bone & joint research · 2026Article
- A 16-Year Longitudinal Study of Long-term Clinical and Radiographic Outcomes in Dorsal Proximal Interphalangeal Joint Fracture-Dislocations.Hand (New York, N.Y.) · 2026Article
- Comparison of innate and adaptive immune responses to joint injury during the onset and progression of post-traumatic osteoarthritis in common murine models.Scientific reports · 2026Article
- Effect of neurodynamic mobilization on lower limb function in patients with mild post-traumatic knee osteoarthritis.World journal of orthopedics · 2026Article
- Resolving curling and swelling in cartilage and other deformation-prone tissue explant models: a scalable, simple load-predictive flattening method enabling standardized mechanical compression.Frontiers in bioengineering and biotechnology · 2026Article
- Dual-center study on AI-driven multi-label deep learning for X-ray screening of knee abnormalities.Scientific reports · 2025Article
- Salivary Flow Rate in Patients with Kidney Failure on Hemodialysis-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Prospective Preference Assessment of a Pharmacological Clinical Trial to Alter the Progression of Posttraumatic Osteoarthritis After ACL Reconstruction.Orthopaedic journal of sports medicine · 2025Article
- The intersection of aging and estrogen in osteoarthritis.npj women's health · 2025Review
- Osteoarthritis early-, mid- and late-stage progression in the rat medial meniscus transection model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Article
- Posttraumatic osteoarthritis after athletic knee injury: A narrative review of diagnostic imaging strategies.PM & R : the journal of injury, function, and rehabilitation · 2025Review
- Chronic intermittent hypobaric hypoxia alleviates early-stage posttraumatic osteoarthritis via NF-κB/Nrf2 pathway in mice.Journal of orthopaedic surgery and research · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of the knee joint is important for diagnosing early disease and developing new and effective preventions or treatments. The aim of this review was to provide detailed clinical data on inflammatory and other biomarkers obtained from patients after acute knee trauma in order to (i) present a timeline of events that occur in the acute, subacute, and chronic post-traumatic phases and in PTOA, and (ii) to identify key factors present in the synovial fluid, serum/plasma and urine, leading to PTOA of the knee in 23-50% of individuals who had acute knee trauma. In this context, we additionally discuss methods of simulating knee trauma and inflammation in in vivo, ex vivo articular cartilage explant and in vitro chondrocyte models, and answer whether these models are representative of the clinical inflammatory stages following knee trauma. Moreover, we compare the pro-inflammatory cytokine concentrations used in such models and demonstrate that, compared to concentrations in the synovial fluid after knee trauma, they are exceedingly high. We then used the Bradford Hill Framework to present evidence that TNF-α and IL-6 cytokines are causal factors, while IL-1β and IL-17 are credible factors in inducing knee PTOA disease progresssion. Lastly, we discuss beneficial infrastructure for future studies to dissect the role of local vs. systemic inflammation in PTOA progression with an emphasis on early disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.