Evidence map›Paper›PMID 33671422›Full record

ReviewToxins2021

Joyce Gonzales, Trinad Chakraborty, Maritza Romero, Mobarak Abu Mraheil, Abdullah Kutlar, Betty Pace, Rudolf Lucas

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Heme-mediated selection of encapsulatedEmerging microbes & infections · 2025
    Article
  3. Review
  4. Endogenously produced HMicrobiology spectrum · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. TheFrontiers in microbiology · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Joyce GonzalesDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Trinad ChakrabortyInstitute for Medical Microbiology, Justus-Liebig-University, Biomedical Research Centre Seltersberg, 35392 Giessen, Germany.ORCID 0000-0002-1452-4759
Maritza RomeroVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-4476-2053
Mobarak Abu MraheilInstitute for Medical Microbiology, Justus-Liebig-University, Biomedical Research Centre Seltersberg, 35392 Giessen, Germany.
Abdullah KutlarDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Betty PaceDepartment of Pediatrics, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Rudolf LucasDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3805-8868
Augusta University · USJustus-Liebig-Universität Gießen · DE

Funding

ENaC-α mediates lung fluid clearance and capillary barrier function in pneumoniaR01HL138410 · NHLBI · AUGUSTA UNIVERSITY · PI LUCAS, RUDOLF · 2018 to 2021
$2.0M
NHLBI NIH HHS R01 HL138410
6 · The paper itself

Abstract

Sickle cell disease (SCD) is one of the most common autosomal recessive disorders in the world. Due to functional asplenia, a dysfunctional antibody response, antibiotic drug resistance and poor response to immunization, SCD patients have impaired immunity. A leading cause of hospitalization and death in SCD patients is the acute chest syndrome (ACS). This complication is especially manifested upon infection of SCD patients with

Indexed as

Acute Chest SyndromeAnemia, Sickle CellAnimalsAnti-Bacterial AgentsBacterial ProteinsHost-Pathogen InteractionsHumansHydrogen PeroxidePneumonia, PneumococcalPrognosisRisk FactorsStreptococcus pneumoniaeStreptolysinsVirulenceVirulence FactorsAnti-Bacterial AgentsBacterial ProteinsHydrogen PeroxideplY protein, Streptococcus pneumoniaeStreptolysinsVirulence Factorsacute chest syndromeH2O2pneumolysinsickle cell diseaseStreptococcus pneumoniae

Identifiers

PMID33671422
PMCPMC7922783
OpenAlexW3129305943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.