ArticleInternational journal of environmental research and public health2021
Increased Risk of Migraine in Patients with Chronic Periodontitis: A Population-Based Cohort Study.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis.European journal of neurology · 2025Pooled it
- Article
- Association of Chronic Periodontitis with Migraine in a Korean Adult Population: A Nationwide Nested Case-Control Study.Healthcare (Basel, Switzerland) · 2025Article
- Association between DMFT and primary headaches: a study based on the Rafsanjan cohort study.BMC oral health · 2024Article
- Association between human herpes simplex virus and severe headache or migraine among aged 20-49 years: a cross-sectional study.Frontiers in neurology · 2024Article
- Exploring the Potential Consortium of Migraine and Periodontitis.International journal of dentistry · 2024Review
- Genetic Predisposition to Periodontitis and Risk of Migraine: A Two-Sample Mendelian Randomization Study.Neurology and therapy · 2023Article
- A registry-based study of tooth-colored restorative materials for decayed teeth in Taiwan.Journal of dental sciences · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is considered to be a neurovascular disease that manifests as a throbbing headache, possibly caused by the activation of the trigeminovascular system. Several studies have supported the role of inflammation in the pathogenesis of migraine. Chronic periodontitis (CP) is an infectious inflammatory disease triggered by bacterial products evoking an immune response which could result in the destruction of the periodontium. However, little is known about the longitudinal association between CP and migraine. In this study, we designed a nationwide population-based cohort study to investigate the risk of migraine and CP exposure in Taiwan. In total, 68,282 patients with CP were identified from the National Health Insurance Research Database (NHIRD), and 68,282 comparisons were randomly captured and matched by age, sex, monthly income, urbanization and comorbidities. The association between CP exposure and migraine risk was evaluated by Cox proportional hazards regression models. In this study, 785 migraine patients were identified in the CP cohort, and 641 migraine cases were found in the non-CP cohort. The incidence rate of migraine was significantly higher in the CP cohort than the non-CP cohort (adjusted HR: 1.21, 95% CI: 1.09-1.34,
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Registered trials
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