Evidence map›Paper›PMID 33671152›Full record

ArticleCancers2021

Increasing Mean Age of Head and Neck Cancer Patients at a German Tertiary Referral Center.

Julius M Vahl, Marlene C Wigand, Michael Denkinger, Dhayana Dallmeier, Chiara Steiger, Claudia Welke, Peter Kuhn, Christian Idel, Johannes Doescher, Adrian von Witzleben and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  11. Influence of travel burden on tumor classification and survival of head and neck cancer patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Julius M VahlDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.ORCID 0000-0002-4481-7085
Marlene C WigandDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.
Michael DenkingerAgaplesion Bethesda Ulm, Geriatric Research Ulm University and Geriatric Center, 89073 Ulm, Germany.ORCID 0000-0002-8097-060X
Dhayana DallmeierAgaplesion Bethesda Ulm, Geriatric Research Ulm University and Geriatric Center, 89073 Ulm, Germany.ORCID 0000-0003-3665-7023
Chiara SteigerDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.
Claudia WelkeClinical Cancer Registry, Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89081 Ulm, Germany.
Peter KuhnClinical Cancer Registry, Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89081 Ulm, Germany.ORCID 0000-0001-5058-1059
Christian IdelDepartment of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany.
Johannes DoescherDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.
Adrian von WitzlebenDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.ORCID 0000-0001-6766-4758
Matthias BrandDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.
Ralf MarienfeldInstitute of Pathology, University Medical Center Ulm, 89081 Ulm, Germany.
Peter MöllerInstitute of Pathology, University Medical Center Ulm, 89081 Ulm, Germany.ORCID 0000-0002-1646-3662
Marie-Nicole TheodorakiDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.
Jens GreveDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.ORCID 0000-0003-0628-0608
Patrick J SchulerDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.ORCID 0000-0002-1065-8709
Cornelia BrunnerDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.ORCID 0000-0002-6456-5508
Thomas K HoffmannDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.
Simon LabanDepartment of Otorhinolaryngology and Head & Neck Surgery, Head and Neck Cancer Center of the Comprehensive Cancer Center Ulm, University Medical Center Ulm, 89075 Ulm, Germany.ORCID 0000-0001-6732-7137
University Hospital Ulm · DEAgaplesion Bethesda Klinik · DEUniversität Ulm · DE

Funding

Deutsche Forschungsgemeinschaft 416718265Deutsche Krebshilfe 70112209Ulm University Clinician scientist program to Simon Laban
6 · The paper itself

Abstract

backgroundThe impact of demographic change on the age at diagnosis in German head and neck cancer (HNC) patients is unclear. Here we present an evaluation of aging trends in HNC at a tertiary referral center.

methodsRetrospective cohort study on aging trends at the initial diagnosis of newly diagnosed patients with HNC between 2004 and 2018 at the head and neck cancer center Ulm in relation to demographic data of the catchment area.

resultsThe study population consisted of 2450 individuals diagnosed with HNC with a mean age of 62.84 (±11.67) years. We observed a significant increase in annual incidence rates and mean age over time. Mean age among HNC patients increased significantly more than among the population in the catchment area. Whereas the incidence rate of patients <50 years did not change, the incidence of HNC patients aged ≥70 years increased the most. The mean patient age in the main tumor sites increased significantly. Surprisingly, HPV-positive patients were not younger than HPV-negative patients, but showed a non-significant trend towards a higher mean age (63.0 vs. 60.7 years).

conclusionsIncreasing incidence rates in older patients pose a challenge for health care systems. A nationwide study is needed to assess the dynamics and impact of aging on the incidence of HNC.

Indexed as

agingdemographicsepidemiologyhead and neck cancerHPV

Identifiers

PMID33671152
PMCPMC7922863
OpenAlexW3130230465

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.