Evidence map›Paper›PMID 33671147›Full record

Trial reportNutrients2021

Resistant Starch Type 2 from Wheat Reduces Postprandial Glycemic Response with Concurrent Alterations in Gut Microbiota Composition.

Riley L Hughes, William H Horn, Peter Finnegan, John W Newman, Maria L Marco, Nancy L Keim, Mary E Kable

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. [Research progress in mechanisms of dietary resistant starch for regulating glucose and lipid metabolism].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Riley L HughesDepartment of Nutrition, University of California, Davis, CA 95616, USA.ORCID 0000-0001-7457-5286
William H HornObesity and Metabolism, Western Human Nutrition Research Center, Agricultural Research Service, USDA, Davis, CA 95616, USA.
Peter FinneganDepartment of Food Science & Technology, University of California, Davis, CA 95616, USA.
John W NewmanDepartment of Nutrition, University of California, Davis, CA 95616, USA.ORCID 0000-0001-9632-6571
Maria L MarcoDepartment of Food Science & Technology, University of California, Davis, CA 95616, USA.
Nancy L KeimDepartment of Nutrition, University of California, Davis, CA 95616, USA.
Mary E KableDepartment of Nutrition, University of California, Davis, CA 95616, USA.

Funding

Agricultural Research Service 2032-51530-025-00DAgricultural Research Service 2032-51530-026-00DInnovation Institute for Food and Health (IIFH) Resistant Starch Wheat for Improved Metabolic Health
6 · The paper itself

Abstract

The majority of research on the physiological effects of dietary resistant starch type 2 (RS2) has focused on sources derived from high-amylose maize. In this study, we conduct a double-blind, randomized, placebo-controlled, crossover trial investigating the effects of RS2 from wheat on glycemic response, an important indicator of metabolic health, and the gut microbiota. Overall, consumption of RS2-enriched wheat rolls for one week resulted in reduced postprandial glucose and insulin responses relative to conventional wheat when participants were provided with a standard breakfast meal containing the respective treatment rolls (RS2-enriched or conventional wheat). This was accompanied by an increase in the proportions of bacterial taxa

Indexed as

AdultBacteriaBlood GlucoseCross-Over StudiesDouble-Blind MethodFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedResistant StarchRNA, BacterialRNA, Ribosomal, 16STriticumBlood GlucoseFatty Acids, VolatileResistant StarchRNA, BacterialRNA, Ribosomal, 16Sglycemic responsegut microbiotametabolismresistant starchshort-chain fatty acidswheat

Identifiers

PMID33671147
PMCPMC7922998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.