Evidence map›Paper›PMID 33671126›Full record

ReviewMicroorganisms2021

Microbial Interkingdom Biofilms and the Quest for Novel Therapeutic Strategies.

Katrien Van Dyck, Rita M Pinto, Durgasruthi Pully, Patrick Van Dijck

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Short Synthesis of Structurally DiverseInternational journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. iScience · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Katrien Van DyckLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Department of Biology, KU Leuven, 3001 Leuven, Belgium.
Rita M PintoLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Department of Biology, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0003-0634-2928
Durgasruthi PullyLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Department of Biology, KU Leuven, 3001 Leuven, Belgium.
Patrick Van DijckLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Department of Biology, KU Leuven, 3001 Leuven, Belgium.ORCID 0000-0002-1542-897X
VIB-KU Leuven Center for Microbiology · BEKU Leuven · BE

Funding

C. albicans and S. aureus Catheter Infections: Clinical Implications and TherapyR01AI130170 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI JABRA-RIZK, MARY ANN Y · 2017 to 2020
$1.5M
Fonds Wetenschappelijk Onderzoek 1181818NFonds Wetenschappelijk Onderzoek W000921NFundação para a Ciência e a Tecnologia SFRH/BD/130319/2017National Institute of Allergy and Infectious Diseases R01AI130170 (NIAID).
6 · The paper itself

Abstract

Fungal and bacterial species interact with each other within polymicrobial biofilm communities in various niches of the human body. Interactions between these species can greatly affect human health and disease. Diseases caused by polymicrobial biofilms pose a major challenge in clinical settings because of their enhanced virulence and increased drug tolerance. Therefore, different approaches are being explored to treat fungal-bacterial biofilm infections. This review focuses on the main mechanisms involved in polymicrobial drug tolerance and the implications of the polymicrobial nature for the therapeutic treatment by highlighting clinically relevant fungal-bacterial interactions. Furthermore, innovative treatment strategies which specifically target polymicrobial biofilms are discussed.

Indexed as

antimicrobial peptidesbiofilmbiofilm matrixCandidaessential oilsnanoparticlespolymicrobialprobioticsquorum sensing

Identifiers

PMID33671126
PMCPMC7921918
OpenAlexW3132819356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.