Evidence map›Paper›PMID 33671124›Full record

ReviewVaccines2021

Strategies for Enhancement of Live-Attenuated

James E Galen, Rezwanul Wahid, Amanda D Buskirk

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Microbial Biotechnology in Medicine.Progress in molecular and subcellular biology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Oral Vaccination with AttenuatedPathogens (Basel, Switzerland) · 2025
    Article
  11. Developing a potent vaccine againstExpert reviews in molecular medicine · 2024
    Review
  12. Article
  13. Live-AttenuatedVaccines · 2023
    Article
  14. Evaluation ofVaccines · 2022
    Article
  15. Mucosal Vaccination: A Promising Alternative Against Flaviviruses.Frontiers in cellular and infection microbiology · 2022
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

James E GalenCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Rezwanul WahidCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-5623-1903
Amanda D BuskirkCenter for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Process and Facilities, Division of Microbiology Assessment II, U.S. Food and Drug Administration, Silver Spring, MD 20903, USA.
University of Maryland, Baltimore · USUnited States Food and Drug Administration · US

Funding

NIH HHS 1R01AI095309-01A1 and 1R56AI125388-01A1
6 · The paper itself

Abstract

The use of live-attenuated bacterial vaccines as carriers for the mucosal delivery of foreign antigens to stimulate the mucosal immune system was first proposed over three decades ago. This novel strategy aimed to induce immunity against at least two distinct pathogens using a single bivalent carrier vaccine. It was first tested using a live-attenuated

Indexed as

carrier vaccinehomeostasisimmunogenicityinflammationSalmonellaTyphi

Identifiers

PMID33671124
PMCPMC7923097
OpenAlexW3132972916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.