Evidence map›Paper›PMID 33671100›Full record

ArticleInternational journal of molecular sciences2021

Comparison of the Efficacy of Two Novel Antitubercular Agents in Free and Liposome-Encapsulated Formulations.

Nikoletta Kósa, Ádám Zolcsák, István Voszka, Gabriella Csík, Kata Horváti, Lilla Horváth, Szilvia Bősze, Levente Herenyi

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  4. Article
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  6. Liposomal delivery system/adjuvant for tuberculosis vaccine.Immunity, inflammation and disease · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nikoletta KósaDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary.
Ádám ZolcsákDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary.
István VoszkaDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary.
Gabriella CsíkDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary.
Kata HorvátiMTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University, Hungarian Academy of Sciences, 1518 Budapest, Hungary.
Lilla HorváthMTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University, Hungarian Academy of Sciences, 1518 Budapest, Hungary.ORCID 0000-0002-1633-3147
Szilvia BőszeMTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University, Hungarian Academy of Sciences, 1518 Budapest, Hungary.
Levente HerenyiDepartment of Biophysics and Radiation Biology, Semmelweis University, 1094 Budapest, Hungary.ORCID 0000-0003-0535-0256
Semmelweis University · HUEötvös Loránd University · HU

Funding

Higher Education Institutional Excellence Program of the Ministry for Innovation and Technology in Hungary, within the framework of the Therapeutic Development thematic program of Semmelweis University: 2019, ELTE Institutional Excellence Program (NKFIH-1 NKFIH-1157-8/2019-DT
6 · The paper itself

Abstract

Tuberculosis is one of the top ten causes of death worldwide, and due to the appearance of drug-resistant strains, the development of new antituberculotic agents is a pressing challenge. Employing an in silico docking method, two coumaran (2,3-dihydrobenzofuran) derivatives-TB501 and TB515-were determined, with promising in vitro antimycobacterial activity. To enhance their effectiveness and reduce their cytotoxicity, we used liposomal drug carrier systems. Two types of small unilamellar vesicles (SUV) were prepared: multicomponent pH-sensitive stealth liposome (SUV

Indexed as

Drug Delivery SystemsAntitubercular AgentsCell ProliferationCells, CulturedDrug CompoundingDrug DesignHumansLiposomesMonocytesMycobacterium tuberculosisTuberculosisAntitubercular AgentsLiposomes2,3-dihydrobenzofuranabsorption spectrometrycolony-forming unitscoumarandynamic light scatteringflow cytometrymonocomponent liposomepH-sensitive stealth liposome

Identifiers

PMID33671100
PMCPMC7957691
OpenAlexW3135693491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.