Trial reportNutrients2021
Low Energy Availability with and without a High-Protein Diet Suppresses Bone Formation and Increases Bone Resorption in Men: A Randomized Controlled Pilot Study.
Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Biochemical Responses to Experimentally Induced Short-Term Low Energy Availability in Athletes: A Systematic Review.Scandinavian journal of medicine & science in sports · 2026Pooled it
- The skeletal safety of milk-derived proteins: A meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- Metabolic signature of short-term low energy availability.Physiological reports · 2025Trial
- Bone biomarker and inflammatory cytokine responses to short-term low energy availability with and without preserved protein intake: a randomized, controlled, multi-period, cross-over trial.European journal of applied physiology · 2026Article
- Effects of endurance exercise and dietary protein intake on osteokine, bone turnover, and inflammatory markers in endurance runners: A narrative review.Bone reports · 2025Review
- Assessment of entropy accumulation in human subjects when exposed to low energy availability.Heliyon · 2024Article
- Impact of Dietary Protein on Osteoporosis Development.Nutrients · 2023Review
- The effects of popular diets on bone health in the past decade: a narrative review.Frontiers in endocrinology · 2023Review
- Short-Term Carbohydrate Restriction Impairs Bone Formation at Rest and During Prolonged Exercise to a Greater Degree than Low Energy Availability.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Screening for Low Energy Availability in Male Athletes: Attempted Validation of LEAM-Q.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Suppression of insulin-like growth factor 1 (IGF-1) and leptin secondary to low energy availability (LEA) may contribute to adverse effects on bone health. Whether a high-protein diet attenuates these effects has not been tested. Seven men completed three five-day conditions operationally defined as LEA (15 kcal kg fat-free mass (FFM)
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.