ReviewInternational journal of molecular sciences2021
The Biochemistry of Phytocannabinoids and Metabolic Engineering of Their Production in Heterologous Systems.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Transcriptomic analysis of fatty acid and cannabinoid synthases in an S1 cannabis progeny segregating for propyl cannabinoid biosynthesis.Plant molecular biology · 2026Article
- Article
- Exploring the Lesser-Known Bioactive Natural Products of Plant Species of the GenusPlants (Basel, Switzerland) · 2025Review
- Effect of Hormonal Treatments on Cannabinoid Content Levels in Female Hemp (International journal of molecular sciences · 2025Article
- Review
- Characterisation of Cannabis glandular trichome development reveals distinct features of cannabinoid biosynthesis.Plant cell reports · 2025Article
- Genotoxicity of selected cannabinoids in human lymphoblastoid TK6 cells.Archives of toxicology · 2024Article
- Rational Design and Modification of NphB for Cannabinoids Biosynthesis.Molecules (Basel, Switzerland) · 2024Article
- Genome-wide identification of cannabinoid biosynthesis genes in non-drug type Cannabis (Cannabis sativa L.) cultivar.Journal of cannabis research · 2024Article
- Hormonal control of promoter activities of Cannabis sativa prenyltransferase 1 and 4 and salicylic acid mediated regulation of cannabinoid biosynthesis.Scientific reports · 2023Article
- Biosynthesis of Phytocannabinoids and Structural Insights: A Review.Metabolites · 2023Review
- Relationship between Total Antioxidant Capacity, Cannabinoids and Terpenoids in Hops and Cannabis.Plants (Basel, Switzerland) · 2023Article
- Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids.Journal of fungi (Basel, Switzerland) · 2023Review
- Oxylipin biosynthetic gene families of Cannabis sativa.PloS one · 2023Article
- Delineating genetic regulation of cannabinoid biosynthesis during female flower development inPlant direct · 2022Article
- A Case Report of Subcutaneously Injected Liposomal Cannabidiol Formulation Used as a Compassion Therapy for Pain Management in a Dog.Frontiers in veterinary science · 2022Article
- High-Titer Production of Olivetolic Acid and Analogs in Engineered Fungal Host Using a Nonplant Biosynthetic Pathway.ACS synthetic biology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The medicinal properties of cannabis and the its legal status in several countries and jurisdictions has spurred the massive growth of the cannabis economy around the globe. The value of cannabis stems from its euphoric activity offered by the unique phytocannabinoid tetrahydrocannabinol (THC). However, this is rapidly expanding beyond THC owing to other non-psychoactive phytocannabinoids with new bioactivities that will contribute to their development into clinically useful drugs. The discovery of the biosynthesis of major phytocannabinoids has allowed the exploration of their heterologous production by synthetic biology, which may lead to the industrial production of rare phytocannabinoids or novel synthetic cannabinoid pharmaceuticals that are not easily offered by cannabis plants. This review summarizes the biosynthesis of major phytocannabinoids in detail, the most recent development of their metabolic engineering in various systems, and the engineering approaches and strategies used to increase the yield.
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