Evidence map›Paper›PMID 33671071›Full record

Trial reportInternational journal of molecular sciences2021

Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic

Kimberley E Freedman, Jessica L Hill, Yuren Wei, Allegra R Vazquez, Diana S Grubb, Roxanne E Trotter, Scott D Wrigley, Sarah A Johnson, Michelle T Foster, Tiffany L Weir

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05750433 nacompletednot on this map

PHAGE 3: Determination of Phage and Probiotic Synergistic Effects on Gastrointestinal Health

TypeinterventionalSponsorColorado State UniversityRan2021 to 2024Enrolled120ConditionsGastrointestinal DysfunctionArmsPreforPro+B. subtilis DE111 probiotics, Placebo, B. subtilis DE111
NCT06154525 nacompletednot on this mapstarted 2024, after this paper: background citation

Evaluating the Effectiveness of the LiveSpo® Preg-Mom and LiveSpo® KIDS Spore Probiotics in Supporting the Reduction of Constipation, Anorexia, and Slow Weight Gain in Children Aged 24-60 Months

TypeinterventionalSponsorAnabio R&DRan2024 to 2024Enrolled201ConditionsConstipation, Anorexia, Weight GainArmsRO water, LiveSpo Preg-Mom, LiveSpo KIDS
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Bacillus Subtilis (BG01-4Nutrients · 2023
    Trial
  7. The probioticGut microbes
    Trial
  8. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  9. Review
  10. Cheonggukjang-DerivedMetabolites · 2026
    Article
  11. Review
  12. Protective Effects and Potential Mechanisms ofAnimals : an open access journal from MDPI · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kimberley E FreedmanIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Jessica L HillAdipose Tissue Biology Laboratory Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-3323-8379
Yuren WeiIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Allegra R VazquezIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Diana S GrubbIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Roxanne E TrotterIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Scott D WrigleyIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Sarah A JohnsonFunctional Foods & Human Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.
Michelle T FosterAdipose Tissue Biology Laboratory Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-3232-6924
Tiffany L WeirIntestinal Health Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-5423-7140
Colorado State University · US

Funding

Deerland Enzymes and Probiotics 5392726
6 · The paper itself

Abstract

Probiotics make up a large and growing segment of the commercial market of dietary supplements and are touted as offering a variety of human health benefits. Some of the purported positive impacts of probiotics include, but are not limited to, stabilization of the gut microbiota, prevention of gastrointestinal disorders and modulation of the host immune system. Current research suggests that the immunomodulatory effects of probiotics are strain-specific and vary in mode of action. Here, we examined the immunomodulatory properties of

Indexed as

AdultAnti-Inflammatory AgentsBacillus subtilisCytokinesDietary SupplementsDouble-Blind MethodFecesFemaleGastrointestinal DiseasesGastrointestinal MicrobiomeGastrointestinal TractHumansImmunomodulationInflammationLeukocytes, MononuclearMaleAnti-Inflammatory AgentsCytokinesBacillus subtilisflow cytometrygastrointestinal healthimmune cellsperipheral blood mononuclear cells (PBMC)probioticshort chain fatty acid

Identifiers

PMID33671071
PMCPMC7957723
OpenAlexW3133978841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.