Evidence map›Paper›PMID 33670982›Full record

ArticleBiomolecules2021

Nourin-Dependent miR-137 and miR-106b: Novel Early Inflammatory Diagnostic Biomarkers for Unstable Angina Patients.

Salwa A Elgebaly, Robert H Christenson, Hossam Kandil, Nashwa El-Khazragy, Laila Rashed, Beshoy Yacoub, Heba Eldeeb, Mahmoud Ali, Roshanak Sharafieh, Ulrike Klueh and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
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  8. Article
  9. Impact of microRNAs on cardiovascular diseases and aging.The Journal of international medical research · 2024
    Review
  10. Article
  11. Article
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  13. Circulating miRNA-106b-5p As a Potential Biomarker for Coronary Artery Disease.International journal of molecular and cellular medicine · 2024
    Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Salwa A ElgebalyResearch & Development, Nour Heart, Inc., Vienna, VA 22180, USA.
Robert H ChristensonDepartment of Pathology, University of Maryland, School of Medicine, Baltimore, MD 2120, USA.
Hossam KandilDepartment of Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt.
Nashwa El-KhazragyDepartment of Clinical Pathology-Hematology, Ain Shams Medical Research Institute (MASRI), Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0001-6646-4674
Laila RashedDepartment of Biochemistry and Molecular Biology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt.
Beshoy YacoubDepartment of Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt.ORCID 0000-0001-5818-1770
Heba EldeebDepartment of Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt.
Mahmoud AliDepartment of Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt.
Roshanak SharafiehDepartment of Surgery, UConn Health, School of Medicine, and Cell & Molecular Tissue Engineering, LLC Farmington, CT 06032, USA.
Ulrike KluehDepartment of Biomedical Engineering, Integrative Biosciences Center (IBio), Wayne State University, Detroit, MI 48202, USA; .
Donald L KreutzerDepartment of Surgery, UConn Health, School of Medicine, and Cell & Molecular Tissue Engineering, LLC, Farmington, CT 06032, USA.
Cairo University · EGCell and Tissue Systems (United States) · USAin Shams University · EGUConn Health · USUniversity of Maryland, Baltimore · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, no blood biomarkers exist that can diagnose unstable angina (UA) patients. Nourin is an early inflammatory mediator rapidly released within 5 min by reversible ischemic myocardium, and if ischemia persists, it is also released by necrosis. Nourin is elevated in acute coronary syndrome (ACS) patients but not in symptomatic noncardiac and healthy subjects. Recently, circulating microRNAs (miRNAs) have been established as markers of disease, including cardiac injury and inflammation.

objectivesTo profile and validate the potential diagnostic value of Nourin-dependent

methodsUsing Nourin amino acid sequence, an integrated bioinformatics analysis was conducted. Analysis indicated that Nourin is a direct target for

resultsGene expression profiles showed that

conclusionsNourin-dependent gene expression of

Indexed as

Early DiagnosisAcute Coronary SyndromeAngina, UnstableApoferritinsCase-Control StudiesFemaleHumansMaleMicroRNAsMiddle AgedRNA, Long NoncodingRNA, MessengerROC CurveApoferritinsFTHL17 protein, humanMicroRNAsMIRN106 microRNA, humanMIRN137 microRNA, humanRNA, Long NoncodingRNA, Messengeracute coronary syndromesinflammatory diagnostic biomarkersmiRNAsNourinreversible myocardial ischemiaunstable angina

Identifiers

PMID33670982
PMCPMC7997347
OpenAlexW3135192105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.