Evidence map›Paper›PMID 33670920›Full record

ArticleInternational journal of molecular sciences2021

Fibrotic Phenotype of Peritumour Mesenteric Adipose Tissue in Human Colon Cancer: A Potential Hallmark of Metastatic Properties.

Maria Tabuso, Raghu Adya, Richard Stark, Kishore Gopalakrishnan, Yee Wah Tsang, Sean James, Andrew White, Adrian Fisk, Federica Dimitri, Mark Christian and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  2. Predictive value ofQuantitative imaging in medicine and surgery · 2025
    Article
  3. A novel 22-bp InDel withinAnimal biotechnology · 2024
    Article
  4. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Maria TabusoDepartment of Gastroenterology, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
Raghu AdyaWarwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Richard StarkSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.ORCID 0000-0001-5676-7604
Kishore GopalakrishnanDepartment of Pathology, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
Yee Wah TsangDepartment of Pathology, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
Sean JamesDepartment of Biomedical Sciences, University Hospital Coventry & Warwickshire, Coventry CV2 2DX, UK.
Andrew WhiteDepartment of Biomedical Sciences, University Hospital Coventry & Warwickshire, Coventry CV2 2DX, UK.
Adrian FiskDepartment of Biomedical Sciences, University Hospital Coventry & Warwickshire, Coventry CV2 2DX, UK.
Federica DimitriDepartment of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.
Mark ChristianDepartment of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.
Ramesh Pulendran ArasaradnamDepartment of Gastroenterology, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.ORCID 0000-0002-2231-3062
University Hospital Coventry · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GBNottingham Trent University · GBUniversity of Warwick · GBUniversity of Leicester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of tumour associated stroma on cancer metastasis is an emerging field. However, cancer associated genes in peritumoral adipose tissue (pAT) in human colon cancer have not been explored. The aim of this study was to identify differentially expressed genes (DEGs) associated with cancer pathways in mesenteric pAT compared with adjacent adipose tissue. In total, nine patients with colon cancer pathological stage T2/T4 were employed in this study. DEGs were identified in 6 patients employing Nanostring PanCancer Pathway Panel and pathway enrichment analyses were performed. Differential expression of the 5 most up-regulated and 2 down regulated genes was validated with qRT-PCR. Results showed collagen type I alpha 1 chain (

Indexed as

Gene Expression Regulation, NeoplasticMesenteryAdipose TissueAgedAged, 80 and overCollagen Type ICollagen Type I, alpha 1 ChainColonic NeoplasmsExtracellular MatrixFemaleGene Expression ProfilingHumansMaleMiddle AgedTumor MicroenvironmentWnt Signaling PathwayCOL1A1 protein, humanCollagen Type ICollagen Type I, alpha 1 Chainadipose tissuecolon cancerextracellular matrixtumour microenvironment

Identifiers

PMID33670920
PMCPMC7957668
OpenAlexW3134705284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.