ArticleInternational journal of molecular sciences2021
Effects of Tyrosine and Tryptophan in Rats with Diet-Induced Obesity.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Chicken IDO2 and TDO2: Biochemical Characteristics and Regulatory Roles in Avian Tryptophan Metabolism and Inflammatory Response.Animals : an open access journal from MDPI · 2026Article
- Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility.Chinese medical journal · 2026Review
- Transcriptomic Analysis of Immune Tolerance Induction in NOD Mice Following Oral Vaccination with GAD65-Vaccines · 2025Article
- Current Data on the Role of Amino Acids in the Management of Obesity in Children and Adolescents.International journal of molecular sciences · 2025Review
- The associations between circulating amino acids and arterial aneurysms and dissection: A bidirectional Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Metabolite profiling of bioactive compounds in tempe flour and its potential as a hypocholesterolemic functional food.Frontiers in nutrition · 2025Article
- Bitter Perception and Effects of Foods Rich in Bitter Compounds on Human Health: A Comprehensive Review.Foods (Basel, Switzerland) · 2024Review
- Effects of soda water on blood lipid and metabolic profiling of urine in hyperlipidemia rats using UPLC/Triple-TOF MS.Heliyon · 2023Article
- Metabolomic phenotyping of obesity for profiling cardiovascular and ocular diseases.Journal of translational medicine · 2023Article
- Lysine Deprivation Suppresses Adipogenesis in 3T3-L1 Cells: A Transcriptome Analysis.International journal of molecular sciences · 2023Article
- Efficacy of Triphala extracts on the changes of obese fecal microbiome and metabolome in the human gut model.Journal of traditional and complementary medicine · 2023Article
- Pharmacotherapy of the Lipid-Lowering Drugs: Update on Efficacy and Risk.International journal of molecular sciences · 2023Article
- Tryptophan Prevents the Development of Non-Alcoholic Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Impacts of essential amino acids on energy balance.Molecular metabolism · 2022Review
- Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum.Biomedicines · 2022Article
- NMR-Based Metabolomics Approach to Investigate the Effects of Fruits ofMetabolites · 2021Article
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Authors and funding
8 authors.
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Abstract
Amino acids tyrosine (Tyr) and tryptophan (Trp) play a significant role in the regulation of energy metabolism, locomotor activity, and eating behavior. We studied the possibility of modulating these processes in obesity by increasing the pool of Tyr and Trp in the experimental diet. As a model of obesity, we used Wistar rats fed a diet with an excess specific energy value (HFCD) for 64 days. Trp led to a normalization of the rats' body weight almost to the control level, but increased anxiety-like behavior and decreased long-term memory. The consumption of amino acids resulted in increased grip strength and impairment of short-term memory. The locomotor activity of animals decreased with age as a result of Tyr consumption, while Trp, on the contrary, prevented this. The Tyr supplementation led to the normalization of triglycerides and LDL. In the spleen cell lysates, amino acids suppressed the production of proinflammatory cytokines. The liver tissue morphology showed that the consumption of Tyr noticeably weakened the signs of fatty degeneration. The addition of Trp, on the contrary, led to an unfavorable effect, consisting of the appearance of a high number of large rounded fatty vacuoles. The data obtained indicate a more pronounced anti-inflammatory effect of Tyr as compared to Trp.
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