ReviewLife (Basel, Switzerland)2021
Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules.
Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The role of minerals in prebiotic evolution: Implications for identifying worlds with the potential for life's origin.Fundamental research · 2026Review
- Parasites constrain within-population diversification while accelerating between-population divergence in an RNA replication system.Molecular biology and evolution · 2026Article
- Hydroxy acid conjugation to lipids increases structural and hydrolytic stability.Nature communications · 2026Article
- Compositional memory matters for early molecular systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Reconstituting alternative life using the test-bed of cell-free systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Selection-diversification interplay in oligonucleotide chemical evolution.Biophysics and physicobiology · 2025Article
- RNA World with Inhibitors.Entropy (Basel, Switzerland) · 2024Article
- Evidence of Heritability in Prebiotically Realistic Membrane-Bound Systems.Life (Basel, Switzerland) · 2024Article
- Constraint on an RNA world on montmorillonite clay.Biophysical journal · 2024Article
- RNA folding studies inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life.Science advances · 2023Article
- Emergence of linkage between cooperative RNA replicators encoding replication and metabolic enzymes through experimental evolution.PLoS genetics · 2023Article
- Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Recent progress in primitive polyester synthesis and membraneless microdroplet assembly.Biophysics and physicobiology · 2023Article
- Hydrophobic-cationic peptides modulate RNA polymerase ribozyme activity by accretion.Nature communications · 2022Article
- Evolutionary transition from a single RNA replicator to a multiple replicator network.Nature communications · 2022Article
- A Mutation Threshold for Cooperative Takeover.Life (Basel, Switzerland) · 2022Article
- Trends and Outlooks in Synthetic Biology: A Special Issue for Celebrating 10 Years ofLife (Basel, Switzerland) · 2022Article
- An Approach to the De Novo Synthesis of Life.Accounts of chemical research · 2022Article
- Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Connecting primitive phase separation to biotechnology, synthetic biology, and engineering.Journal of biosciences · 2021Review
Corrections and comments
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2 authors.
Funding
Abstract
Sustainable replication and evolution of genetic molecules such as RNA are likely requisites for the emergence of life; however, these processes are easily affected by the appearance of parasitic molecules that replicate by relying on the function of other molecules, while not contributing to their replication. A possible mechanism to repress parasite amplification is compartmentalization that segregates parasitic molecules and limits their access to functional genetic molecules. Although extent cells encapsulate genomes within lipid-based membranes, more primitive materials or simple geological processes could have provided compartmentalization on early Earth. In this review, we summarize the current understanding of the types and roles of primitive compartmentalization regarding sustainable replication of genetic molecules, especially from the perspective of the prevention of parasite replication. In addition, we also describe the ability of several environments to selectively accumulate longer genetic molecules, which could also have helped select functional genetic molecules rather than fast-replicating short parasitic molecules.
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