Evidence map›Paper›PMID 33670758›Full record

ArticleInternational journal of molecular sciences2021

Increased Regulatory T Cells and Decreased Myeloid-Derived Suppressor Cells Induced by High CCL17 Levels May Account for Normal Incidence of Cancers among Patients with Atopic Dermatitis.

Sohshi Morimura, Makoto Sugaya, Tomonori Oka, Hiraku Suga, Tomomitsu Miyagaki, Yuichiro Tsunemi, Yoshihide Asano, Shinichi Sato

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Single-cell transcriptome analysis reveals DNMT1Journal of translational medicine · 2026
    Article
  3. Constructing a chemokine-based model and identifyingTranslational cancer research · 2025
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sohshi MorimuraDepartment of Dermatology, International University of Health and Welfare, Chiba 286-8520, Japan.
Makoto SugayaDepartment of Dermatology, International University of Health and Welfare, Chiba 286-8520, Japan.ORCID 0000-0002-1618-329X
Tomonori OkaDepartment of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.ORCID 0000-0001-7362-3207
Hiraku SugaDepartment of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.
Tomomitsu MiyagakiDepartment of Dermatology, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.ORCID 0000-0003-1879-3128
Yuichiro TsunemiDepartment of Dermatology, Saitama Medical University, Saitama 350-0495, Japan.ORCID 0000-0003-3590-6489
Yoshihide AsanoDepartment of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.ORCID 0000-0001-5560-9778
Shinichi SatoDepartment of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.
The University of Tokyo · JPInternational University of Health and Welfare · JPSaitama Medical University · JPSt. Marianna University School of Medicine · JP

Funding

Japan Society for the Promotion of Science 16K10146
6 · The paper itself

Abstract

The incidence of cancers in atopic dermatitis (AD) is not increased, although the Th2-dominant environment is known to downregulate tumor immunity. To gain mechanistic insights regarding tumor immunity in AD, we utilized CCL17 transgenic (TG) mice overexpressing CCL17, which is a key chemokine in AD. Tumor formation and lung metastasis were accelerated in CCL17 TG mice when melanoma cells were injected subcutaneously or intravenously. Flow cytometric analysis showed increases in regulatory T cells (Tregs) in lymph nodes in CCL17 TG mice with high mRNA levels of

Indexed as

AnimalsChemokine CCL17Chemotactic FactorsDermatitis, AtopicDown-RegulationHumansImmunityIncidenceLung NeoplasmsMice, TransgenicModels, BiologicalMyeloid-Derived Suppressor CellsNeoplasmsSkin NeoplasmsTh2 CellsT-Lymphocytes, RegulatoryCCL17 protein, humanChemokine CCL17Chemotactic Factorsatopic dermatitisCCL17myeloid-derived suppressor cellstumor immunity

Identifiers

PMID33670758
PMCPMC7922104
OpenAlexW3132069908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.