Evidence map›Paper›PMID 33670526›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Exacerbation of AMD Phenotype in Lasered CNV Murine Model by Dysbiotic Oral Pathogens.

Pachiappan Arjunan, Radhika Swaminathan, Jessie Yuan, Mohamed Elashiry, Amany Tawfik, Mohamed Al-Shabrawey, Pamela M Martin, Thangaraju Muthusamy, Christopher W Cutler

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Oxidative Stress and Inflammation in Retinal Degeneration.Antioxidants (Basel, Switzerland) · 2021
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Pachiappan ArjunanDepartment of Periodontics, Dental College of Georgia, Augusta, GA 30912, USA.ORCID 0000-0001-9470-1171
Radhika SwaminathanDepartment of Periodontics, Dental College of Georgia, Augusta, GA 30912, USA.
Jessie YuanDepartment of Periodontics, Dental College of Georgia, Augusta, GA 30912, USA.
Mohamed ElashiryDepartment of Periodontics, Dental College of Georgia, Augusta, GA 30912, USA.
Amany TawfikVision Discovery Institute, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-0245-8256
Mohamed Al-ShabraweyVision Discovery Institute, Augusta University, Augusta, GA 30912, USA.
Pamela M MartinVision Discovery Institute, Augusta University, Augusta, GA 30912, USA.
Thangaraju MuthusamyDepartment of Biochemistry & Molecular Biology, Augusta University, Augusta, GA 30912, USA.
Christopher W CutlerDepartment of Periodontics, Dental College of Georgia, Augusta, GA 30912, USA.
Augusta University · US

Funding

Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Homocysteine's role in Age-Related Macular DegenerationR01EY029751 · NEI · OAKLAND UNIVERSITY · PI TAWFIK, AMANY M · 2019 to 2023
$1.8M
NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY029751
6 · The paper itself

Abstract

Emerging evidence underscores an association between age-related macular degeneration (AMD) and periodontal disease (PD), yet the biological basis of this linkage and the specific role of oral dysbiosis caused by PD in AMD pathophysiology remains unclear. Furthermore, a simple reproducible model that emulates characteristics of both AMD and PD has been lacking. Hence, we established a novel AMD+PD murine model to decipher the potential role of oral infection (ligature-enhanced) with the keystone periodontal pathogen

Indexed as

age-related macular degenerationantioxidantsoxidative stressperiodontal diseaseretinal degenerationretinal inflammationtherapeutic targets

Identifiers

PMID33670526
PMCPMC7922506
OpenAlexW3132287463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.