Evidence map›Paper›PMID 33670447›Full record

ArticleBiomolecules2021

Serum Long Non-Coding RNAs PVT1, HOTAIR, and NEAT1 as Potential Biomarkers in Egyptian Women with Breast Cancer.

Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Olfat Gamil Shaker, Amal Mohamed Kamal, Nancy Nabil Shahin

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  14. Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers.Journal of cell communication and signaling · 2023
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  18. lncRNA PVT1: a novel oncogene in multiple cancers.Cellular & molecular biology letters · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amal Ahmed Abd El-FattahBiochemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, Cairo 11562, Egypt.
Nermin Abdel Hamid SadikBiochemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, Cairo 11562, Egypt.
Olfat Gamil ShakerMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.
Amal Mohamed KamalBiochemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, Cairo 11562, Egypt.ORCID 0000-0002-8036-1185
Nancy Nabil ShahinBiochemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, Cairo 11562, Egypt.ORCID 0000-0002-9746-5335
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs play an important role in tumor growth, angiogenesis, and metastasis in several types of cancer. However, the clinical significance of using lncRNAs as biomarkers for breast cancer diagnosis and prognosis is still poorly investigated. In this study, we analyzed the serum expression levels of lncRNAs PVT1, HOTAIR, NEAT1, and MALAT1, and their associated proteins, PAI-1, and OPN, in breast cancer patients compared to fibroadenoma patients and healthy subjects. Using quantitative real-time PCR (qRT-PCR), we compared the serum expression levels of the four circulating lncRNAs in patients with breast cancer (

Indexed as

AdultBiomarkers, TumorBreast NeoplasmsEnzyme-Linked Immunosorbent AssayFemaleFibroadenomaGene Expression Regulation, NeoplasticHumansLogistic ModelsPlasminogen Activator Inhibitor 1RNA, Long NoncodingBiomarkers, TumorMALAT1 long non-coding RNA, humanNEAT1 long non-coding RNA, humanPlasminogen Activator Inhibitor 1PVT1 long-non-coding RNA, humanRNA, Long Noncodingbreast cancerfibroadenomaHOTAIRMALAT1NEAT1OPNPAI-1PVT1

Identifiers

PMID33670447
PMCPMC7922136
OpenAlexW3133429610

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.