ReviewBiomedicines2021
Translational Research in FLASH Radiotherapy-From Radiobiological Mechanisms to In Vivo Results.
Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Review
- Oxygen Depletion and the Role of Cellular Antioxidants in FLASH Radiotherapy: Mechanistic Insights from Monte Carlo Radiation-Chemical Modeling.Antioxidants (Basel, Switzerland) · 2025Article
- Resistance to Radiotherapy in Cancer.Diseases (Basel, Switzerland) · 2025Review
- Exploring the Metabolic Impact of FLASH Radiotherapy.Cancers · 2025Review
- FLASH-RT for pulmonary protection: a comprehensive review of mechanisms, technological advances, and clinical translation.Frontiers in oncology · 2025Review
- Emergence of FLASH‑radiotherapy across the last 50 years (Review).Oncology letters · 2024Review
- FLASH radiotherapy: bridging revolutionary mechanisms and clinical frontiers in cancer treatment - a narrative review.Ewha medical journal · 2024Review
- Harnessing progress in radiotherapy for global cancer control.Nature cancer · 2023Review
- FLASH Radiotherapy and the Use of Radiation Dosimeters.Cancers · 2023Review
- Proton Beam Therapy in the Oligometastatic/Oligorecurrent Setting: Is There a Role? A Literature Review.Cancers · 2023Review
- Radical Production with Pulsed Beams: Understanding the Transition to FLASH.International journal of molecular sciences · 2022Article
- A potential revolution in cancer treatment: A topical review of FLASH radiotherapy.Journal of applied clinical medical physics · 2022Review
- Application of a novel diamond detector for commissioning of FLASH radiotherapy electron beams.Medical physics · 2022Article
- Article
- Neuroprotective Effects of Ultra-High Dose Rate FLASH Bragg Peak Proton Irradiation.International journal of radiation oncology, biology, physics · 2022Article
- Radiobiological and Treatment-Related Aspects of Spatially Fractionated Radiotherapy.International journal of molecular sciences · 2022Review
- Optical Filter-Embedded Fiber-Optic Radiation Sensor for Ultra-High Dose Rate Electron Beam Dosimetry.Sensors (Basel, Switzerland) · 2021Article
- Microbeam Radiotherapy-A Novel Therapeutic Approach to Overcome Radioresistance and Enhance Anti-Tumour Response in Melanoma.International journal of molecular sciences · 2021Review
- Innovative radiotherapies for the treatment of glioblastoma.Neuro-oncology advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy. Thus far, most in vitro and in vivo results show a real potential of FLASH to offer superior normal tissue sparing compared to conventionally delivered radiation. While there are several postulations behind the differential behaviour among normal and cancer cells under FLASH, the full spectra of radiobiological mechanisms are yet to be clarified. Currently the number of devices delivering FLASH dose rate is few and is mainly limited to experimental and modified linear accelerators. Nevertheless, FLASH research is increasing with new developments in all the main areas: radiobiology, technology and clinical research. This paper presents the current status of FLASH radiotherapy with the aforementioned aspects in mind, but also to highlight the existing challenges and future prospects to overcome them.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.